Dysregulation of affect in multiple sclerosis: New phenomenological approach
Open accessAbstract
Disorders involving regulation of affect commonly occur in multiple sclerosis (MS). These include various clinical presentations with inconsistent definitions that lead to many nomenclatures. In order to simplify the clinical approach to dysregulation of affect (DyA) a phenomenological definition was applied that unifies and combines the current classifications. Accordingly, the prevalence of DyA was determined in MS patients and comorbidity was evaluated with psychiatric disorders. Using the Structured Clinical Interview for DSM-III-R (SCID), 651 consecutive MS patients were assessed (474 female, 177 male, mean age 43.6 years, mean disease duration 11.5 years) and it was found that the prevalence of DyA was 6.5% (n = 42). In 14 patients (33.3% of DyA patients) there was no associated psychiatric comorbidity, while in 28 patients (66.6%) there was comorbid psychopathology; 12 had been suffering from psychosis (28.6%), eight from mood disorders (19%), six from cognitive decline (14.3%) and two from personality disorder (4.7%). In 15 patients (35.7%) the DyA was ego-dystonic and in 27 patients (64.3%) the symptoms of DyA were ego-syntonic. All patients with comorbid psychosis had ego-syntonic DyA. In 14.3% of patients the DyA symptomatology preceded the appearance of MS. It is concluded that the new phenomenological definition of DyA aids in distinguishing this symptom from other psychopathologies and can serve as a tool for neurologists in defining this unique entity.
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FND and functional disorders are known for a high frequency of psychiatric comorbidity and disturbances in emotional regulation that have also been found in MS.
“Nonetheless, FND and functional disorders also are known for a high frequency of psychiatric comorbidity as well as disturbances in emotional regulation that have also been found in MS [56].”
From Functional neurological disorder and multiple sclerosis: a systematic review of misdiagnosis and clinical overlap (2022) · cites this paper as [56]
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- Authors
- HAREL, Y., BARAK, Y., & ACHIRON, A.
- Affiliations
- Tel Aviv University (IL)
- Corresponding author
- HAREL, YERMI
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2007-01-12
- Volume
- 61
- Issue
- 1
- Pages
- 94-98
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W2048476831
- Cited by
- 27
- References
- 0
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- multiple sclerosis, mood disorders, prevalence, psychiatric comorbidity, psychosis, cognitive decline, personality disorders
- MeSH terms
- Adult, Affect, Mental Disorders, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Psychiatric Status Rating Scales, Retrospective Studies, Cohort Studies, Databases, Factual, Mood Disorders
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