MECHANISM OF THE FORMATION OF MEGAMITOCHONDRIA BY COPPER‐CHELATING AGENTS IV. ROLE OF FUSION PHENOMENON IN THE CUPRIZONE‐INDUCED MEGAMITOCHONDRIAL FORMATION
Abstract
Megamitochondria were induced within 36-40 hours in mouse hepatocytes by injecting cuprizone into the peritoneal cavity. Induction of megamitochondria was dependent upon the amount and the time intervals of the injection of cuprizone: 200 mg of cuprizone/kg of body weight-injected every 12 hours or 400 mg of cuprizone/kg of body weight-injected every 24 hours. When the latter amount of the noxious reagent was administered to the animal every 12 hours, fatty changes of the liver was observed. Involvement of the fusion phenomenon in the mechanism of megamitochondrial formation is discussed in the light of turnover rates for various components of the mitochondrion.
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Cuprizone selectively affects oligodendrocytes.
“Nevertheless, a consensus seems to be that cuprizone selectively affects oligodendrocytes.”
From Strain differences in cuprizone induced demyelination (2017) · cites this paper as [20]
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Praet, J., Guglielmetti, C., Berneman, Z., Van der Linden, A., & Ponsaerts, P. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.004 · Cited by 435 · see citing works
Strain differences in cuprizone induced demyelination
Yu, Q., Hui, R., Park, J., Huang, Y., Kusnecov, A. W., Dreyfus, C. F., & Zhou, R. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0181-3 · Cited by 40 · see citing works
- Authors
- Asano, M., Wakabayashi, T., Ishikawa, K., & Kishimoto, H.
- Affiliations
- Nagoya City University (JP)
- Corresponding author
- Wakabayashi, Takashi
- ORCID
- Ishikawa, Kumiko
- Venue
- Acta Pathologica Japonica
- Publisher
- Wiley
- Published
- 1978-03
- Volume
- 28
- Issue
- 2
- Pages
- 205-213
- ISSN
- 0001-6632 (ISSN-L)
- OpenAlex
- W2157874397
- Cited by
- 13
- References
- 0
- Citations by year
- 2023: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2014: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Pathologica Japonica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- megamitochondria, cuprizone, copper chelating agents, mitochondrial fusion, hepatocytes, liver fatty change, mitochondrial turnover, copper toxicity
- MeSH terms
- Animals, Cuprizone, Cyclohexanes, Male, Mitochondria, Liver, Mice
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