CoChat
Sign Up
Cited by 65

The DOI matches its Crossref record.

Expression of standard CD44 in human colorectal carcinoma: Association with prognosis

Huh, Jung Wook, Kim, Hyeong Rok, Kim, Young Jin, Lee, Jae Hyuk, Park, Yeon Sun, Cho, Sang Hyuk, Joo, Jae Kyoon·2009·Pathology International
DOI 10.1111/j.1440-1827.2009.02357.x
Open this paper in CoChat — free account

Abstract

The aim of the present study was to evaluate the expression of standard CD44 (CD44s) in colorectal cancer (CRC), its relationship with clinicopathological characteristics, and its potential prognostic significance. CD44s levels were measured on immunohistochemistry in tumors and surrounding normal mucosa from 74 patients with primary colorectal carcinomas. The patients were followed for a median period of 37 months. Expression of CD44s in primary tumor and surrounding normal mucosa tissues was demonstrated in 100% (74/74) and 37.9% (28/74), respectively. The expression of CD44s in tumors was significantly associated with the depth of invasion (P = 0.034) and lymph node involvement (P = 0.031). A significant difference was observed between the overall survival and level of tumor CD44s expression, especially for stage IV carcinoma (P = 0.038). Multivariate analysis indicated that TNM stage (P = 0.020) and tumor CD44s expression (P = 0.008) were independent predictors of overall survival in adenocarcinomas. CD44s overexpression may be an independent unfavorable prognostic factor for overall survival in advanced CRC, especially stage IV disease. Further investigation, however, is necessary to assess the biological roles of CD44 in CRC, and validate their possible value as novel therapeutic targets.

Overview

Integrity signals

Registry

Crossref · 10.1111/j.1440-1827.2009.02357.x

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 21

  1. Furuta K, 1996, Relationship between cd44 expression and cell proliferation in epithelium and stroma of colorectal neoplasms, Am J Pathol, 149, 1147
  2. 10.1038/bjc.1993.354 · DOI
  3. 10.1081/CNV-200039658 · DOI
  4. 10.1080/00365529850170900 · DOI
  5. 10.1083/jcb.120.1.227 · DOI
  6. Ylagan LR, 2000, Cd44: A marker of squamous differentiation in adenosquamous neoplasms, Arch Pathol Lab Med, 124, 212, 10.5858/2000-124-0212-C · DOI
  7. 10.1177/29.4.6166661 · DOI
  8. Hart IR, 1989, Molecular aspects of the metastatic cascade, Biochim Biophys Acta, 989, 65
  9. Koopman G, 1990, Triggering of the CD44 antigen on T lymphocytes promotes T cell adhesion through the LFA‐1 pathway, J Immunol, 145, 3589, 10.4049/jimmunol.145.11.3589 · DOI
  10. 10.1111/1523-1747.ep12874646 · DOI
  11. 10.1002/1097-0215(20010101)91:1<67::AID-IJC1011>3.0.CO;2-D · DOI
  12. 10.1111/j.1440-1827.2006.01946.x · DOI
  13. 10.1016/0959-8049(95)00252-E · DOI
  14. 10.1002/(SICI)1097-0215(20000215)85:4<523::AID-IJC13>3.0.CO;2-6 · DOI
  15. 10.1002/(SICI)1097-0215(19960621)69:3<218::AID-IJC12>3.0.CO;2-3 · DOI
  16. 10.1111/j.1440-1827.2006.01925.x · DOI
  17. 10.1038/bjc.1996.364 · DOI
  18. 10.1016/S0046-8177(98)80014-2 · DOI
  19. 10.1002/1097-0142(20000815)89:4<733::AID-CNCR3>3.0.CO;2-# · DOI
  20. 10.1056/NEJMra040958 · DOI
  21. Tachikawa D, 2000, Do the expression of CD44, apoptosis and thymidylate synthase inhibition rate correlate with the efficacy of chemotherapy in colorectal cancer?, Anticancer Res, 20, 595

Cited by

Sorted by citations

Metadata

Authors
Huh, J. W., Kim, H. R., Kim, Y. J., Lee, J. H., Park, Y. S., Cho, S. H., & Joo, J. K.
Venue
Pathology International
Publisher
Wiley
Published
2009-03-30
Volume
59
Issue
4
Pages
241-246
ISSN
  • 1320-5463
  • 1440-1827
DOI
10.1111/j.1440-1827.2009.02357.x
Cited by
65
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review