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HYDATID DISEASE: THE ALVEOLAR VARIETY IN AUSTRALIA. A CASE REPORT WITH COMMENT ON THE TOXICITY OF MEBENDAZOLE
Abstract
The alveolar form of hydatid disease, caused by the larval stage of the cestode Echinococcus multilocularis, is virtually confined geographically to the northern hemisphere. It produces clinically malignant multivesicular infiltrating lesions most often in the liver, and is quite different from the usual cystic variety caused by E. granulosus. We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.
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“However, when these drugs are used for prolonged periods to treat tissue helminthiases [36], cancers [37,38], or even when they are used just for once as preventive chemotherapy for intestinal helminths [39], liver toxicity, allergic reactions, and rarely severe myelosuppression (in particular, neutropenia) may occur.”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [36]
In the citing paper
“Granulocytopenia, alopecia, pruritus, skin abscess, and arthritis were reported in patients treated with high doses of mebendazole [36,238,327].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [36]
In the citing paper
“It was reported in treatment of echinococcosis for which long-term mebendazole therapy was needed [36,325,326].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [36]
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Research works printed but not linked: 29
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- Frerichs F., 1861, A Clinical Treatise on Diseases of the Liver, 225
- Virchow R., 1856, Die multiloculare, ulcerirende Echinokokkeng eschwulst der Leber, Verh. Phys. Med. Ges. Wurzburg, 61, 84
- 10.1007/BF00935054 · DOI
- 10.1007/BF02469332 · DOI
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Cited by
Sorted by citations
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Metadata
- Authors
- Braithwaite, P. A., Thomas, R. J. S., & Thompson, R. C. A.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Murdoch University (AU)
- Corresponding author
- Braithwaite, Peter Allen
- ORCID
- Thomas, R. J. S.
- Venue
- Australian and New Zealand Journal of Surgery
- Publisher
- Wiley
- Published
- 1985-10
- Volume
- 55
- Issue
- 5
- Pages
- 519-523
- ISSN
- 0004-8682 (ISSN-L)
- OpenAlex
- W2076350631
- Cited by
- 12
- References
- 0
- Citations by year
- 2023: 3 · 2021: 1 · 2016: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian and New Zealand Journal of Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Keywords
- alveolar echinococcosis, echinococcosis, Echinococcus multilocularis, hair loss, granulocytopenia, liver lesions, Australia
- MeSH terms
- Agranulocytosis, Alopecia, Australia, Echinococcosis, Hepatic, Female, Humans, Japan, Liver, Mebendazole, Middle Aged
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- This page
- CoChat. (2026). Citation check: HYDATID DISEASE: THE ALVEOLAR VARIETY IN AUSTRALIA. A CASE REPORT WITH COMMENT ON THE TOXICITY OF MEBENDAZOLE. https://app.cochat.ai/papers/10.1111/j.1445-2197.1985.tb00935.x
- The paper
- Braithwaite, P. A., Thomas, R. J. S., & Thompson, R. C. A. (1985). HYDATID DISEASE: THE ALVEOLAR VARIETY IN AUSTRALIA. A CASE REPORT WITH COMMENT ON THE TOXICITY OF MEBENDAZOLE. Australian and New Zealand Journal of Surgery. https://doi.org/10.1111/j.1445-2197.1985.tb00935.x