Human fascioliasis successfully treated with triclabendazole
Abstract
Fascioliasis, caused by the common liver fluke Fusciolu hepatica , is an endemic infection in sheep and cattle in many parts of Australia. Infections in humans in Australia have been reported infrequently and the most appropriate therapy for human fascioliasis remains to be determined. This case report describes a patient with the infection unsuccessfully treated with multiple high doses of praziquantel, mebendazole or albendazole. The infection was successfully eliminated by the administration of triclabendazole in two single doses of 900 mg (12 mg/kg) two days apart. No side effects were observed after the treatment. Based on our experience and that recently reported in the literature, triclabendazole may be regarded as the drug of choice for the treatment of human fascioliasis. (Aust NZ J Med 1992; 22: 45–47.)
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Most treatments of human fascioliasis with albendazole were unsuccessful.
“Subsequently, albendazole began to be used for human fascioliasis; however, most of the treatments were unsuccessful [256–258]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [256]
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286 · see citing works
- Authors
- Laird, P. P., & Boray, J. C.
- Corresponding author
- Laird, P. P.
- Venue
- Australian and New Zealand Journal of Medicine
- Publisher
- Wiley
- Published
- 1992-02
- Volume
- 22
- Issue
- 1
- Pages
- 45-47
- ISSN
- 0004-8291 (ISSN-L)
- OpenAlex
- W2045356050
- Cited by
- 32
- References
- 0
- Citations by year
- 2021: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian and New Zealand Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Keywords
- human fascioliasis, Fasciola hepatica, triclabendazole, anthelmintic treatment, praziquantel, mebendazole, albendazole, drug resistance
- MeSH terms
- Triclabendazole, Aged, Anthelmintics, Benzimidazoles, Cholestasis, Fascioliasis, Food Contamination, Humans, Male, Abdominal Pain
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