The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reversal of Rigidity and Improvement in Motor Performance by Subthalamic High‐frequency Stimulation in MPTP‐treated Monkeys
Abstract
In Parkinson's disease the loss of dopaminergic neurons in the substantia nigra is associated with global disorganization of basal ganglia activity and, in particular, with increased activity of the excitatory glutamatergic neurons of the subthalamic nucleus. Recent experimental studies have shown that parkinsonian symptoms can be alleviated by selective lesioning of the subthalamic nucleus in monkeys treated with 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP). We measured the effect of high‐frequency stimulation of the subthalamic nucleus in two unilaterally MPTP‐treated monkeys in order to determine whether it was possible to obtain reversible, gradual and controllable functional impairment of this structure. Clinical, mechanographic and electromyographic results demonstrate that this technique can alleviate parkinsonian rigidity and bradykinesia without causing dyskinesia or hemiballismus. This study supports the hypothesis that the subthalamic nucleus and its excitatory projections have an important role in the mechanisms sustaining the expression of parkinsonian motor changes, and suggests that high‐frequency stimulation of the subthalamic nucleus could be included in treatment for parkinsonism.
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Citations
Cites
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
Alexander, G. E., & Crutcher, M. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90107-l · Cited by 4,131
Cited by
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Lozano, A. M., Lipsman, N., Bergman, H., Brown, P., Chabardes, S., Chang, J. W., Matthews, K., McIntyre, C. C., Schlaepfer, T. E., Schulder, M., et al. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0128-2 · Cited by 1,450
Parent, A., & Hazrati, L.-N. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00008-d · Cited by 1,358
Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
Benabid, A. L., Chabardes, S., Mitrofanis, J., & Pollak, P. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70291-6 · Cited by 1,285
Deep brain stimulation for Parkinson’s disease
Benabid, A. L. (2003) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.11.001 · Cited by 1,046
The pedunculopontine nucleus and Parkinson's disease
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Metadata
- Authors
- Benazzouz, A., Gross, C., Féger, J., Boraud, T., & Bioulac, B.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 1993-04
- Volume
- 5
- Issue
- 4
- Pages
- 382-389
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1990280414
- Cited by
- 642
- References
- 1
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Benazzouz, A., Gross, C., Féger, J., Boraud, T., & Bioulac, B. (1993). Reversal of Rigidity and Improvement in Motor Performance by Subthalamic High‐frequency Stimulation in MPTP‐treated Monkeys. European Journal of Neuroscience. https://doi.org/10.1111/j.1460-9568.1993.tb00505.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
