Net influx of plasma 6‐[18F]fluoro‐l‐DOPA (FDOPA) to the ventral striatum correlates with prefrontal processing of affective stimuli
Open accessAbstract
Dopaminergic neurotransmission in the ventral and dorsal striatum interact with central processing of rewarding and reward‐indicating stimuli, and may affect frontocortical–striatal–thalamic circuits regulating goal‐directed behaviour. Thirteen healthy male volunteers were investigated with multimodal imaging, using the radioligand 6‐[18 F]fluoro‐l‐DOPA (FDOPA) for positron emission tomography (PET) measurements of dopamine synthesis capacity, and also functional magnetic resonance imaging (fMRI) in a cognitive activation paradigm. We calculated the correlation between FDOPA net blood–brain influx (; ml/g/min) in the ventral and associative dorsal striatum and BOLD signal changes elicited by standardized affectively positive, negative and neutral visual stimuli. The magnitude of in the ventral striatum was positively correlated with BOLD signal increases in the left anterior cingulate cortex and right insular operculum elicited by positive vs. neutral stimuli, but not negative vs. neutral stimuli. In the dorsal striatum, the magnitude of was positively correlated with processing of positive and negative stimuli in the left dorsolateral prefrontal cortex. These findings suggest that dopamine synthesis capacity in the ventral striatum correlates with the attentional processing of rewarding positive stimuli in the anterior cingulate cortex of healthy subjects. Dopaminergic neurotransmission in the associative dorsal striatum has been associated previously with habit learning. The observed correlation between dopamine synthesis capacity in the dorsal striatum and BOLD signal changes in the dorsolateral prefrontal cortex suggests dopaminergic modulation of processing of emotional stimuli in brain areas associated with motor planning and executive behaviour control.
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Administering dopamine agents to healthy subjects led to a correlation between dopamine uptake in the striatum and BOLD activity in the dorsolateral PFC, suggesting the striatum might drive working memory activity in the PFC.
“Consistent with this idea, Siessmeier et al. (2006) found that administering DA agents to healthy subjects led to a correlation between DA uptake in the striatum and BOLD activity in the dorsolateral PFC, suggesting that the striatum might drive WM activity in the PFC.”
From Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task (2013) · cites this paper as Siessmeier et al. (2006)
The Abstract (page unavailable) reports a correlation between striatal FDOPA influx and dorsolateral prefrontal BOLD activity in healthy subjects. But the BOLD response was measured during affective-stimulus processing, not a working-memory task. The PET methods describe FDOPA administration to measure dopamine synthesis capacity, and the Discussion explicitly cautions that the correlation does not establish that the striatum drives cortical activity. (LLM, conf=0.90)
Experimental — accuracy not yet measuredTYR is involved in the monitoring of cognitive representations.
“In view of the evidence that striatal dopaminergic pathways play a major role in the updating of WM (Siessmeier et al., 2006; Cools et al., 2008; Moustafa et al., 2008), our findings further suggest that TYR is involved in the monitoring of cognitive representations.”
From Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task (2013) · cites this paper as Siessmeier et al., 2006
The Introduction (page unavailable) says dopamine neurotransmission in the associative dorsal striatum interacts with executive functions, including working memory. The Discussion (page unavailable) mentions a suggested relationship between striatal dopamine and the capacity to update working memory, but does not establish that striatal pathways play a major role in updating it. The statement about TYR is the citing authors’ own inference, not a finding attributed to this source. (LLM, conf=0.83)
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References 71 · Cited by 48
Research works printed but not linked: 8
- Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L.S., Weiss, R., Cooper, T.B., Mann, J.J., Van Heertum, R.L., Gorman, J.M. & Laruelle, M. (2000) Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proc. Natl Acad. Sci. USA, 97, 8104-8109.
- Canli, T., Desmond, J.E., Zhao, Z. & Gabrieli, J.D.E. (2002) Sex differences in the neural basis of emotional memories. Proc. Natl Acad. Sci. USA, 99, 10789-10794.
- First, M.B., Spitzer, R.L., Gibbon, M. & Williams, J. (1997) Structured Clinical Interview for DSM-IV Personality Disorders, (SCID-II). American Psychi- atric Press, Inc, Washington, DC.
- First, M.B., Spitzer, R.L., Gibbon, M. & Williams, J. (2001) Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition with Psychotic Screen (SCID-I ⁄ P W ⁄ PSY SCREEN). New York State Psychiatric Institute, Biometrics Research, New York.
- Gjedde, A. (1988) Exchange diffusion of large neutral amino acids between blood and brain. In Rakic, L., Begley, D.J., Davson, H. & Zlokovic, B.V. Peptide and Amino Acid Transport Mechanisms in the Central Nervous System. Stockton Press, New York, pp. 209-217.
- Gjedde, A., Reith, J., Dyve, S., Leger, G., Guttman, M., Diksic, M., Evans, A. & Kuwabara, H. (1991) Dopa decarboxylase activity of the living human brain. Proc. Natl Acad. Sci. USA, 88, 2721-2725.
- Laruelle, M., Abi-Dargham, A., van Dyck, C.H., Gil, R., D'Souza, C.D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S.S., Baldwin, R.M., Seibyl, J.P., Krystal, J.H., Charney, D.S. & Innis, R.B. (1996) Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proc. Natl Acad. Sci. USA, 93, 9235-9240.
- Talairach, J. & Tournoux, P. (1988) Co-Planar Stereotaxic Atlas of the Human Brain 3-Dimensional Proportional System. An Approach to Cerebral Imaging. Thieme, Stuttgart, New York.
- Authors
- Siessmeier, T., Kienast, T., Wrase, J., Larsen, J. L., Braus, D. F., Smolka, M. N., Buchholz, H. G., Schreckenberger, M., Rösch, F., Cumming, P., Mann, K., Bartenstein, P., & Heinz, A.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Charité – Universitätsmedizin Berlin (DE)
- Central Institute of Mental Health (DE)
- Universität Hamburg (DE)
- Corresponding author
- Heinz, Andreas
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2006-07
- Volume
- 24
- Issue
- 1
- Pages
- 305-313
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2133733644
- Cited by
- 48
- References
- 71
- Citations by year
- 2024: 1 · 2022: 1 · 2019: 1 · 2017: 3 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- FDOPA, dopamine synthesis capacity, ventral striatum, dorsal striatum, emotional stimuli, reward processing, anterior cingulate cortex, dorsolateral prefrontal cortex, dopamine signaling, emotional processing, habit learning, goal-directed behavior
- MeSH terms
- Adult, Affect, Caudate Nucleus, Corpus Striatum, Dihydroxyphenylalanine, Dopamine, Fluorine Radioisotopes, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Synaptic Transmission, Photic Stimulation, Putamen, Prefrontal Cortex, Radiopharmaceuticals, Positron-Emission Tomography
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