Bacterial pathogens and the autophagic response
Open accessAbstract
The host cell recognition and removal of invading pathogens are crucial for the control of microbial infections. However, several microorganisms have developed mechanisms that allow them to survive and replicate intracellularly. Autophagy is an ubiquitous physiological pathway in eukaryotic cells, which maintains the cellular homeostasis and acts as a cell quality control mechanism to eliminate aged organelles and unnecessary structures. In addition, autophagy has an important role as a housekeeper since cells that have to get rid of invading pathogens use this pathway to assist this eradication. In this review we will summarize some strategies employed by bacterial pathogens to modulate autophagy to their own benefit and, on the other hand, the role of autophagy as a protective process of the host cell. In addition, we will discuss here recent studies that show the association of LC3 to a pathogen-containing compartment without a classical autophagic sequestering process (i.e. formation of a double membrane structure).
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The autophagic machinery following pathogen entry into cells can target either bacteria-containing phagosomes or free cytosolic bacteria.
“The autophagic machinery following the entry of the pathogen into cells can target either bacteria-containing phagosomes, or free cytosolic bacteria [8,9,10,11].”
From LC3-Associated Phagocytosis (LAP): Connections with Host Autophagy (2012) · cites this paper as [11]
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- Authors
- Lerena, M. C., Vázquez, C. L., & Colombo, M. I.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Colombo, MarÃa I.
- Venue
- Cellular Microbiology
- Publisher
- Hindawi Limited
- Published
- 2010-01
- Volume
- 12
- Issue
- 1
- Pages
- 10-18
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W2068713513
- Cited by
- 35
- References
- 4
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cellular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidad Nacional de Cuyo
- Hospital for Sick Children
- Agencia Nacional de Promoción Científica y Tecnológica (PICT2004)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- autophagy, pathogenic bacteria, host-pathogen interaction, intracellular bacterial replication, host defense against infection, LC3
- MeSH terms
- Animals, Autophagy, Bacteria, Bacterial Proteins, Humans, Microtubule-Associated Proteins, Models, Biological
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