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Increased Diene Conjugates in Diabetic Subjects with Microangiopathy
Abstract
Free radicals are highly reactive unstable chemical species which have been implicated in the vascular damage associated with several disease states. Diene conjugates, probable products of free radical activity on lipids, were measured spectrophotometrically in 26 diabetic patients with microangiopathy, 36 uncomplicated diabetic patients, and 36 healthy controls. Total diene conjugates and diene conjugate to triglyceride ratios were signficantly elevated in diabetic patients with microangiopathy (0.57±0.08 and 0.31±0.14 OD units/ml respectively; mean ±SD) when compared with patients without complications (0.32±0.10, p<0.001, and 0.17±0.06, OD units/ml, p<0.011). There was no difference in total diene conjugation and their ratio to triglycerides between healthy controls and uncomplicated diabetic patients and the results were not influenced by the type of diabetes or level of diabetic control. Diene conjugate ratios repeated in 14 patients on two occasions, 6 weeks apart, with stable metabolic control were consistent. Increased diene conjugation suggesting increased free radical activity is associated with microangiopathy and this may have pathogenetic implications.
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Cited by
Ageing and diabetes: implications for brain function
Biessels, G. J., van der Heide, L. P., Kamal, A., Bleys, R. L. A. W., & Gispen, W. H. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01486-3 · Cited by 458
Relationships between plasma measures of oxidative stress and metabolic control in NIDDM
Nourooz-Zadeh, J., Rahimi, A., Tajaddini-Sarmadi, J., Tritschler, H., Rosen, P., Halliwell, B., & Betteridge, D. J. (1997) · Diabetologia · doi:10.1007/s001250050729 · Cited by 303
Diabetic neuropathy and oxidative stress
Pop-Busui, R., Sima, A., & Stevens, M. (2006) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.625 · Cited by 286
Plasma malondialdehyde in type 1 and type 2 diabetic patients
Gallou, G., Ruelland, A., Legras, B., Maugendre, D., Allannic, H., & Cloarec, L. (1993) · Clinica Chimica Acta · doi:10.1016/0009-8981(93)90114-j · Cited by 167
Elhadd, T. A., Kennedy, G., Hill, A., McLaren, M., Newton, R. W., Greene, S. A., & Belch, J. J. F. (1999) · Diabetes/Metabolism Research and Reviews · doi:10.1002/(sici)1520-7560(199911/12)15:6<405::aid-dmrr69>3.0.co;2-h · Cited by 94
Metadata
- Authors
- Jennings, P. E., Jones, A. F., Florkowski, C. M., Lunec, J., & Barnett, A. H.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 1987-09-10
- Volume
- 4
- Issue
- 5
- Pages
- 452-456
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2051690136
- Cited by
- 163
- References
- 0
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jennings, P. E., Jones, A. F., Florkowski, C. M., Lunec, J., & Barnett, A. H. (1987). Increased Diene Conjugates in Diabetic Subjects with Microangiopathy. Diabetic Medicine. https://doi.org/10.1111/j.1464-5491.1987.tb00908.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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