Nesidioblastosis in an Elderly Patient
Abstract
We report an 84-year-old woman with hypoglycaemia and hyperinsulinaemia caused by diffuse nesidioblastosis. This is the oldest case of nesidioblastosis so far recorded. The case illustrates some of the difficulties in diagnosing inappropriate hyperinsulinaemia and the benefits of surgery, even in old age. Hypoglycaemia should be considered in patients with variable mental function.
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It is estimated that about 1 in 10,000,000 people are diagnosed with idiopathic/sporadic adult-onset nesidioblastosis annually.
“It is estimated that about 1 in 10,000,000 people are diagnosed with this disease annually [45-48].”
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Noninsulinoma pancreatogenous hypoglycemia syndrome: An update in 10 surgically treated patients
Thompson, G. B., Service, F. J., Andrews, J. C., Lloyd, R. V., Natt, N., van Heerden, J. A., & Grant, C. S. (2000) · Surgery · doi:10.1067/msy.2000.110243 · Cited by 121 · see citing works
Noninsulinoma Pancreatogenous Hypoglycemia Syndrome: A Rare Case of Adult-onset Nesidioblastosis
TSUJINO, M., SUGIYAMA, T., NISHIDA, K., TAKADA, Y., TAKANISHI, K., ISHIZAWA, M., & HIRATA, Y. (2005) · Internal Medicine · doi:10.2169/internalmedicine.44.843 · Cited by 24 · see citing works
Nesidioblastosis with Glucagon-Reactive Islet Cell Hyperplasia: A Case Report
Martignoni, M. E., Kated, H., Stiegler, M., Büchler, M. W., Friess, H., Zimmermann, A., Schirp, U., & Nitzsche, E. U. (2003) · Pancreas · doi:10.1097/00006676-200305000-00016 · Cited by 17 · see citing works
Dieterle, M. P., Husari, A., Prozmann, S. N., Wiethoff, H., Stenzinger, A., Röhrich, M., Pfeiffer, U., Kießling, W. R., Engel, H., Sourij, H., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11061741 · Cited by 5 · see citing works
- Authors
- Walmsley, D., Matheson, N. A., Ewen, S., Himsworth, R. L., & Bevan, J. S.
- Affiliations
- Aberdeen Royal Infirmary (GB)
- Corresponding author
- Walmsley, D.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 1995-06
- Volume
- 12
- Issue
- 6
- Pages
- 542-545
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2109645974
- Cited by
- 27
- References
- 0
- Citations by year
- 2026: 1 · 2023: 2 · 2019: 1 · 2017: 1 · 2015: 1 · 2012: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- nesidioblastosis, hypoglycemia, hyperinsulinemia, elderly patients, pancreatic islet hyperplasia, surgical treatment, differential diagnosis
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Hypoglycemia, Insulin, Pancreatic Diseases
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