The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Plasma endothelin response to acute hypoglycaemia in adults with Type 1 diabetes
Abstract
Aims To determine whether acute insulin‐induced hypoglycaemia provokes a detectable alteration in peripheral plasma endothelin (ET) concentrations in humans with Type 1 diabetes. Methods Serial plasma concentrations of ET were measured in 20 patients with Type 1 diabetes during controlled hypoglycaemia induced by intravenous infusion of soluble insulin. Results A significant increase was observed in plasma ET concentrations, from 3.80 ± 0.31 pg/ml at baseline to 6.72 ± 1.47 pg/ml at 60 min after the onset of the hypoglycaemic reaction (P < 0.05). Conclusions Acute insulin‐induced hypoglycaemia induces a rise in plasma endothelin concentrations in people with Type 1 diabetes. This finding is consistent with a putative role for ET in the mediation of hypoglycaemia‐induced vasoconstriction, and the possible precipitation of macrovascular or microvascular events.
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“Hypoglycemia also increases inflammatory and immune markers and results in a prothrombotic state.”
From Stress, hypoglycemia, and the autonomic nervous system (2022) · cites this paper as Wright et al., 2007
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Cites
Association of Hypoglycemia and Cardiac Ischemia
Desouza, C., Salazar, H., Cheong, B., Murgo, J., & Fonseca, V. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1485 · Cited by 406
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Cited by
Vascular disease and diabetes: Is hypoglycaemia an aggravating factor?
Wright, R. J., & Frier, B. M. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.865 · Cited by 336
Self-citationEffects of Acute Insulin-Induced Hypoglycemia on Indices of Inflammation
Wright, R. J., Newby, D. E., Stirling, D., Ludlam, C. A., Macdonald, I. A., & Frier, B. M. (2010) · Diabetes Care · doi:10.2337/dc10-0013 · Cited by 208
Self-citationStress, hypoglycemia, and the autonomic nervous system
Haas, A., Borsook, D., Adler, G., & Freeman, R. (2022) · Autonomic Neuroscience · doi:10.1016/j.autneu.2022.102983 · Cited by 30
Baroreflex sensitivity impairment during hypoglycemia: implications for cardiovascular control
Rao, A. D., Bonyhay, I., Dankwa, J., Baimas-George, M., Kneen, L., Ballatori, S., Freeman, R., & Adler, G. K. (2016) · Diabetes · doi:10.2337/db15-0871 · Cited by 25
Metadata
- Authors
- Wright, R. J., Macleod, K. M., Perros, P., Johnston, N., Webb, D. J., & Frier, B. M.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2007-06-08
- Volume
- 24
- Issue
- 9
- Pages
- 1039-1042
- ISSN
- 0742-3071
- 1464-5491
- Cited by
- 24
- References
- 1
- Language
- en
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