The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Patient‐reported outcomes following islet cell or pancreas transplantation (alone or after kidney) in Type 1 diabetes: a systematic review
Open accessAbstract
Aims For selected individuals with complex Type 1 diabetes, pancreatic islet transplantation (IT) offers the potential of excellent glycaemic control without significant hypoglycaemia, balanced by the need for ongoing systemic immunosuppression. Increasingly, patient-reported outcomes (PROs) are considered alongside biomedical outcomes as a measure of transplant success. PROs in IT have not previously been compared directly with the closest alternate treatment option, pancreas transplant alone (PTA) or pancreas after kidney (PAK). Methods We used a Population, Intervention, Comparisons, Outcomes (PICO) strategy to search Scopus and screened 314 references for inclusion. Results Twelve studies [including PRO assessment of PAK, PTA, islet-after kidney (IAK) and islet transplant alone (ITA); n = 7-205] used a total of nine specified and two unspecified PRO measures. Results were mixed but identified some benefits which remained apparent up to 36 months post-transplant, including improvements in fear of hypoglycaemia, as well as some aspects of diabetes-specific quality of life (QoL) and general health status. Negative outcomes included short-term pain associated with the procedure, immunosuppressant side effects and depressed mood associated with loss of graft function. Conclusions The mixed results may be attributable to limited sample sizes. Also, some PRO measures may lack sensitivity to detect actual changes, as they exclude issues and domains of life likely to be important…
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Islet transplant outcomes can translate into improved patient-reported outcomes, but research in this area is limited.
“These outcomes can translate into improved patientreported outcomes, but research in this area is limited (241).”
Citations
Cites
Five-Year Follow-Up After Clinical Islet Transplantation
Ryan, E. A., Paty, B. W., Senior, P. A., Bigam, D., Alfadhli, E., Kneteman, N. M., Lakey, J. R. T., & Shapiro, A. M. J. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2060 · Cited by 1,641
Fear of hypoglycemia: quantification, validation, and utilization
Cox, D. J., Irvine, A., Gonder-Frederick, L., Nowacek, G., & Butterfield, J. (1987) · Diabetes Care · doi:10.2337/diacare.10.5.617 · Cited by 579
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Holt, R. I. G., DeVries, J. H., Hess-Fischl, A., Hirsch, I. B., Kirkman, M. S., Klupa, T., Ludwig, B., Nørgaard, K., Pettus, J., Renard, E., et al. (2021) · Diabetes Care · doi:10.2337/dci21-0043 · Cited by 699
Metadata
- Authors
- Speight, J., Reaney, M. D., Woodcock, A. J., Smith, R. M., & Shaw, J. A. M.
- Affiliations
- Advocates for Human Potential (United States) (US)
- Royal Holloway University of London (GB)
- Southmead Hospital (GB)
- Newcastle University (GB)
- Corresponding author
- Speight, J.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2010-06-30
- Volume
- 27
- Issue
- 7
- Pages
- 812-822
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2167968923
- Cited by
- 64
- References
- 2
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 8 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 6 · 2012: 5
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Diabetes UK
- Agency for Healthcare Research and Quality
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- type 1 diabetes, islet transplantation, pancreas transplantation, patient-reported outcomes, quality of life, fear of hypoglycemia, immunosuppressive drug adverse effects, patient satisfaction
- MeSH terms
- Diabetes Mellitus, Type 1, Female, Graft Survival, Humans, Immunosuppressive Agents, Male, Quality of Life, Kidney Transplantation, Pancreas Transplantation, Islets of Langerhans Transplantation, Treatment Outcome, Self Report
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