The Pre-diabetes Risk Education and Physical Activity Recommendation and Encouragement (PREPARE) programme study: are improvements in glucose regulation sustained at 2 years?: Long-term evaluation of PREPARE
Abstract
Objective To determine whether improvements in glucose regulation following the PREPARE structured education programme were sustained at 24 months. Patients and methods Ninety-eight overweight or obese individuals with impaired glucose tolerance were randomized to receive: (1) advice leaflet, (2) 3-h structured education programme aimed at promoting physical activity, (iii) 3-h structured education with personalized pedometer use. The primary outcome was change in 2-h post-challenge plasma glucose. Results Seventy-three (74%) individuals were included for analysis at 24 months; age 65 ± 8 years, BMI 29.3 ± 4.8 kg/m(2), South Asian ethnicity 21%. A statistically significant reduction in 2-h glucose of -1.6 mmol/l (-0.4 to -2.7) was seen in the education-with-pedometer group compared with the control group. There is no significant difference in the education-only group. Conclusion Improvements in glucose regulation following a pragmatic group-based structured education with pedometer use were sustained at 24 months.
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Fourteen articles were not included in the meta-analysis because they provided insufficient data for analyses or because they reported outcomes from a trial already included in the analysis but with data from other follow-up times.
“Fourteen articles were not included in the meta-analysis because they provided insufficient data for analyses (i.e., did not report SEs for outcomes and authors did not respond to requests for these data) (23–27) or because these articles reported outcomes from a trial already included in the analysis but with data from other follow-up times (28–36).”
From Global diabetes prevention interventions: A systematic review and network meta-analysis of the real-world impact on incidence, weight, and glucose (2018) · cites this paper as [28]
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The role of physical activity in the management of impaired glucose tolerance: a systematic review
Yates, T., Khunti, K., Bull, F., Gorely, T., & Davies, M. J. (2007) · Diabetologia · doi:10.1007/s00125-007-0638-8 · Cited by 161 · see citing works
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Hemmingsen, B., Gimenez-Perez, G., Mauricio, D., Roqué i Figuls, M., Metzendorf, M.-I., & Richter, B. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003054.pub4 · Cited by 316 · see citing works
Galaviz, K. I., Weber, M. B., Straus, A., Haw, J. S., Narayan, K. M. V., & Ali, M. K. (2018) · Diabetes Care · doi:10.2337/dc17-2222 · Cited by 289 · see citing works
Lakerveld, J., Bot, S. D., Chinapaw, M. J., van Tulder, M. W., Kostense, P. J., Dekker, J. M., & Nijpels, G. (2013) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-10-47 · Cited by 84 · see citing works
- Authors
- Yates, T., Davies, M. J., Sehmi, S., Gorely, T., & Khunti, K.
- Affiliations
- University of Leicester (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Loughborough University (GB)
- Corresponding author
- Yates, T.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2011-09-19
- Volume
- 28
- Issue
- 10
- Pages
- 1268-1271
- ISSN
- 0742-3071 (ISSN-L)
- OpenAlex
- W2119612662
- Cited by
- 56
- References
- 1
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 6 · 2013: 9 · 2012: 7
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Funders
- National Institute for Health and Care Research
- Diabetes UK
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- prediabetes, impaired glucose tolerance, glucose regulation, structured education programme, physical activity, pedometers, overweight, obesity, South Asian ethnicity, sustained effects
- MeSH terms
- Aged, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Health Promotion, Humans, Health Knowledge, Attitudes, Practice, Male, Middle Aged, Motor Activity, Obesity, Patient Education as Topic, Prediabetic State, Body Mass Index, Walking, Glucose Intolerance, Waist Circumference
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