The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Estimating the Proportion of True Null Hypotheses, with application to DNA Microarray Data
Abstract
Summary: We consider the problem of estimating the proportion of true null hypotheses, π0, in a multiple-hypothesis set-up. The tests are based on observed p-values. We first review published estimators based on the estimator that was suggested by Schweder and Spjøtvoll. Then we derive new estimators based on nonparametric maximum likelihood estimation of the p-value density, restricting to decreasing and convex decreasing densities. The estimators of π0 are all derived under the assumption of independent test statistics. Their performance under dependence is investigated in a simulation study. We find that the estimators are relatively robust with respect to the assumption of independence and work well also for test statistics with moderate dependence.
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Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
The control of the false discovery rate in multiple testing under dependency
Benjamini, Y., & Yekutieli, D. (2001) · The Annals of Statistics · doi:10.1214/aos/1013699998 · Cited by 10,490
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692
An improved Bonferroni procedure for multiple tests of significance
SIMES, R. J. (1986) · Biometrika · doi:10.1093/biomet/73.3.751 · Cited by 2,396
Identifying differentially expressed genes using false discovery rate controlling procedures
Reiner, A., Yekutieli, D., & Benjamini, Y. (2003) · Bioinformatics · doi:10.1093/bioinformatics/btf877 · Cited by 1,765
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limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
Assigning Significance to Peptides Identified by Tandem Mass Spectrometry Using Decoy Databases
Käll, L., Storey, J. D., MacCoss, M. J., & Noble, W. S. (2008) · Journal of Proteome Research · doi:10.1021/pr700600n · Cited by 607
Correlation and Large-Scale Simultaneous Significance Testing
Efron, B. (2007) · Journal of the American Statistical Association · doi:10.1198/016214506000001211 · Cited by 405
A unified approach to false discovery rate estimation
Strimmer, K. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-303 · Cited by 406
Metadata
- Authors
- Langaas, M., Lindqvist, B. H., & Ferkingstad, E.
- Venue
- Journal of the Royal Statistical Society Series B: Statistical Methodology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-08-17
- Volume
- 67
- Issue
- 4
- Pages
- 555-572
- ISSN
- 1369-7412 (ISSN-L)
- 1467-9868
- OpenAlex
- W2065311047
- Cited by
- 316
- References
- 5
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Langaas, M., Lindqvist, B. H., & Ferkingstad, E. (2005). Estimating the Proportion of True Null Hypotheses, with application to DNA Microarray Data. Journal of the Royal Statistical Society Series B: Statistical Methodology. https://doi.org/10.1111/j.1467-9868.2005.00515.x
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