Cited by 359Essential Oils and Antimicrobial ActivityAntifungal resistance and susceptibilityAntimicrobial agents and applications

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Antifungal activity of Thymus oils and their major compounds

Pina‐Vaz, C, Gonçalves Rodrigues, A, Pinto, E, Costa‐de‐Oliveira, S, Tavares, C, Salgueiro, L, Cavaleiro, C, Gonçalves, MJ, Martinez‐de‐Oliveira, J·2004·Journal of the European Academy of Dermatology and Venereology

DOI 10.1111/j.1468-3083.2004.00886.x

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Abstract

The increasing recognition and importance of fungal infections, the difficulties encountered in their treatment and the increase in resistance to antifungals have stimulated the search for therapeutic alternatives. Essential oils have been used empirically. The essential oils of Thymus (Thymus vulgaris, T. zygis subspecies zygis and T. mastichina subspecies mastichina) have often been used in folk medicine. The aim of the present study was to evaluate objectively the antifungal activity of Thymus oils according to classical bacteriological methodologies - determination of the minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) - as well as flow cytometric evaluation. The effect of essential oils upon germ tube formation, an important virulence factor, was also studied. The mechanism of action was studied by flow cytometry, after staining with propidium iodide. The chemical composition of the essential oils was investigated by gas chromatography (GC) and gas chromatography/mass spectroscopy (GC/MS). The antifungal activity of the major components (carvacrol, thymol, p-cymene and 1,8-cineole) and also possible interactions between them were also investigated. The essential oils of T. vulgaris and T. zygis showed similar antifungal activity, which was greater than T. mastichina. MIC and MLC values were similar for all the compounds tested. At MIC values of the essential oils, propidium iodide rapidly penetrated the majority of the yeast cells, indicating that the fungicidal effect resulted primarily from an extensive lesion of the cell membrane. Concentrations below the MIC values significantly inhibited germ tube formation. This study describes the potent antifungal activity of the essential oils of Thymus on Candida spp., warranting future therapeutical trials on mucocutaneous candidosis.

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Authors: Pina‐Vaz, C., Gonçalves Rodrigues, A., Pinto, E., Costa‐de‐Oliveira, S., Tavares, C., Salgueiro, L., Cavaleiro, C., Gonçalves, M., & Martinez‐de‐Oliveira, J.
Affiliations: Universidade do Porto (PT)
University of Coimbra (PT)
Hospital de São João (PT)
Corresponding author: Tavares, C
ORCID: Pina‐Vaz, C
Pinto, E
Costa‐de‐Oliveira, S
Salgueiro, L
Cavaleiro, C
Martinez‐de‐Oliveira, J
Venue: Journal of the European Academy of Dermatology and Venereology
Publisher: Wiley
Published: 2003-12-17
Volume: 18
Issue: 1
Pages: 73-78
ISSN: 0926-9959 (ISSN-L)
1468-3083
DOI: 10.1111/j.1468-3083.2004.00886.x
OpenAlex: W2001646769
Semantic Scholar: 65d68ea8cecc4baec6de8193976ce58db33d0242
Cited by: 359
References: 22
Citations by year: 2026: 8 · 2025: 7 · 2024: 13 · 2023: 19 · 2022: 24 · 2021: 22 · 2020: 20 · 2019: 15 · 2018: 12 · 2017: 22 · 2016: 16 · 2015: 20 · 2014: 15 · 2013: 25 · 2012: 20
FWCI: 11.85
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of the European Academy of Dermatology and Venereology (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação para a Ciência e a Tecnologia
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Keywords: antifungal activity, thyme, Thymus zygis, Thymus mastichina, Candida, minimum inhibitory concentration, minimal lethal concentration, germ tube formation, carvacrol, thymol, p-cymene, 1,8-cineole, cell membrane damage, mucocutaneous candidiasis, essential oil composition
MeSH terms: Antifungal Agents, Candida, Flow Cytometry, Phytotherapy, Oils, Volatile, Plants, Medicinal, Plant Structures, Lamiaceae, Plant Preparations

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Antifungal activity of Thymus oils and their major compounds

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