Methylphenidate and cognitive perseveration in hyperactive children
Abstract
Effects of methylphenidate on cognitive flexibility were investigated in 26 children with Attention Deficit Hyperactivity Disorder (ADHD), by assessing perseverative errors on the Wisconsin Card Sorting Test (WCST) and the emergence of clinical symptoms indicative of cognitive perseveration. A double-blind, placebo-control, randomized crossover design was used in which each child was assessed twice in each drug condition (placebo, 0.3 and 1.0 mg/kg). Results indicated that methylphenidate increased perseverative errors on the first assessment but decreased them on the second; clinical symptoms of perseveration occurred at both assessments. Findings suggest that MPH may reduce cognitive flexibility temporarily in some ADHD children.
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The impairment in PFC function with higher doses of stimulants observed in animals may also impede cognitive flexibility in patients with ADHD.
“The impairment in PFC function with higher doses of stimulants observed in animals may also impede cognitive flexibility in patients with ADHD (134).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [134]
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References 29 · Cited by 59
- Authors
- Tannock, R., & Schachar, R.
- Affiliations
- Hospital for Sick Children (CA)
- Corresponding author
- Tannock, Rosemary
- ORCID
- Schachar, Russell
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 1992-10
- Volume
- 33
- Issue
- 7
- Pages
- 1217-1228
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- OpenAlex
- W2048635090
- Cited by
- 59
- References
- 29
- Citations by year
- 2025: 2 · 2023: 3 · 2021: 2 · 2020: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Psychology and Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- methylphenidate, cognitive flexibility, attention deficit hyperactivity disorder, hyperactive children, Wisconsin Card Sorting Test, stimulant medication effects, perseverative errors
- MeSH terms
- Attention, Attention Deficit Disorder with Hyperactivity, Child, Cognition, Concept Formation, Discrimination Learning, Dose-Response Relationship, Drug, Double-Blind Method, Female, Frontal Lobe, Humans, Male, Methylphenidate, Neuropsychological Tests, Problem Solving, Set, Psychology
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