The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Methylphenidate improves working memory and set‐shifting in AD/HD: relationships to baseline memory capacity
Abstract
Objective: Catecholamine stimulant drugs are highly efficacious treatments for attention deficit/hyperactivity disorders (AD/HD). Catecholamine modulation in humans influences performance of numerous cognitive tasks, including tests of attention and working memory (WM). Clear delineation of the effects of methylphenidate upon such cognitive functions in AD/HD would enhance understanding of the effects of drug treatment. Method: Here we present a double‐blind, placebo‐controlled study of the cognitive effects of an acute dose of methylphenidate ( c . .5 mg/kg) in 14 boys aged 10.86 (±1.19) years meeting criteria for DSM‐IV AD/HD. Current behaviour was ascertained using Conners’ teacher and parent self‐report questionnaires and IQ was tested using sub‐tests from WISC‐III‐UK. Tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) were selected to assess visuo‐spatial recognition memory, spatial WM, planning, visual‐search and attentional‐set shifting. Results: Methylphenidate improved spatial WM, attentional‐set shifting and visual‐search task performance. Correlational analyses suggested possible relationships between WM capacity and spatial WM performance improvement. Also, poor performance on the attentional‐set shifting task on placebo was associated with increased errors on the spatial WM task on placebo. Conclusions: Methylphenidate may selectively improve both underlying cognitive difficulties in tasks dependent on intact fronto‐striatal structures, and clinical symptoms of AD/HD. Pre‐treatment measures may have some predictive value in determining individual differences in drug response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
- STATISTICAL PACKAGE FOR SOCIAL SCIENCES
(2014) · Statistical Methods in Psychiatry Research and SPSS · doi:10.1201/b17560-26 · Cited by 12,056
Specific impairments of planning
Shallice, T. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0082 · Cited by 3,741
Executive functions and developmental psychopathology.
Pennington, B. F., & Ozonoff, S. (1996) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1996.tb01380.x · Cited by 3,150 · cited 1×
“Children with attention deficit/hyperactivity disorder (AD/HD) present with both behavioural and cognitive problems (DSM-IV, Pennington & Ozonoff, 1996).”
BackgroundGrant, D. A., & Berg, E. (1948) · Journal of Experimental Psychology · doi:10.1037/h0059831 · Cited by 2,244
Planning and spatial working memory following frontal lobe lesions in man
Owen, A. M., Downes, J. J., Sahakian, B. J., Polkey, C. E., & Robbins, T. W. (1990) · Neuropsychologia · doi:10.1016/0028-3932(90)90137-d · Cited by 1,245
Self-citationSome effects of frontal lobectomy in man
Milner, B. A. (1964) · Medical Entomology and Zoology · Cited by 910
Vaidya, C. J., Austin, G., Kirkorian, G., Ridlehuber, H. W., Desmond, J. E., Glover, G. H., & Gabrieli, J. D. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14494 · Cited by 845
Zahrt, J., Taylor, J. R., Mathew, R. G., & Arnsten, A. F. T. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08528.1997 · Cited by 796
Assessment of children's intelligence and special abilities
Sattler, J. M. (1982) · Medical Entomology and Zoology · Cited by 786
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gerasimov, M., Maynard, L., Ding, Y.-S., Gatley, S. J., Gifford, A., & Franceschi, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-j0001.2001 · Cited by 770
Research works printed but not linked: 7
- Charney D.S., 1986, Abnormal regulation of adrenergic function in panic disorder, American Journal of Psychiatry, 43, 1042
- Conners C.K., 1997, Conner's Rating Scale – revised. Technical manual
- 10.1111/j.1469-7610.1986.tb02330.x · doi:10.1111/j.1469-7610.1986.tb02330.x · Paper page
- Mehta M.A., 2001, Stimulant drugs and AD/HD: Basic and clinical neuroscience, 303
- Milner B., 1964, The frontal granular cortex and behaviour
- 10.1037/0022-006X.65.1.150 · DOI · Paper page
- Weschler D., 1992, Weschler Intelligence Scale for Children – third edition UK
Cited by
sagvolden, T., johansen, E. B., aase, H., & russell, V. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000075 · Cited by 1,035
Cools, R. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.024 · Cited by 903
Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder
Valera, E. M., Faraone, S. V., Murray, K. E., & Seidman, L. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.011 · Cited by 891
del Campo, N., Chamberlain, S. R., Sahakian, B. J., & Robbins, T. W. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.036 · Cited by 685
Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks
Arnsten, A. F. T. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.027 · Cited by 493
Metadata
- Authors
- Mehta, M. A., Goodyer, I. M., & Sahakian, B. J.
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 2004-01-22
- Volume
- 45
- Issue
- 2
- Pages
- 293-305
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- OpenAlex
- W1995785377
- Cited by
- 259
- References
- 71
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Methylphenidate improves working memory and set‐shifting in AD/HD: relationships to baseline memory capacity. https://app.cochat.ai/papers/10.1111/j.1469-7610.2004.00221.x
- The paper
- Mehta, M. A., Goodyer, I. M., & Sahakian, B. J. (2004). Methylphenidate improves working memory and set‐shifting in AD/HD: relationships to baseline memory capacity. Journal of Child Psychology and Psychiatry. https://doi.org/10.1111/j.1469-7610.2004.00221.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
