Cited by 357Ion channel regulation and functionHearing, Cochlea, Tinnitus, GeneticsNeuroscience and Neuropharmacology Research

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Contribution of the Kv3.1 potassium channel to high‐frequency firing in mouse auditory neurones

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Wang, Lu‐Yang, Gan, Li, Forsythe, Ian D., Kaczmarek, Leonard K.·1998·The Journal of Physiology

DOI 10.1111/j.1469-7793.1998.183bo.xPMC PMC2230948

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Abstract

1. Using a combination of patch-clamp, in situ hybridization and computer simulation techniques, we have analysed the contribution of potassium channels to the ability of a subset of mouse auditory neurones to fire at high frequencies. 2. Voltage-clamp recordings from the principal neurones of the medial nucleus of the trapezoid body (MNTB) revealed a low-threshold dendrotoxin (DTX)-sensitive current (ILT) and a high-threshold DTX-insensitive current (IHT). 3. IHT displayed rapid activation and deactivation kinetics, and was selectively blocked by a low concentration of tetraethylammonium (TEA; 1 mM). 4. The physiological and pharmacological properties of IHT very closely matched those of the Shaw family potassium channel Kv3.1 stably expressed in a CHO cell line. 5. An mRNA probe corresponding to the C-terminus of the Kv3.1 channel strongly labelled MNTB neurones, suggesting that this channel is expressed in these neurones. 6. TEA did not alter the ability of MNTB neurones to follow stimulation up to 200 Hz, but specifically reduced their ability to follow higher frequency impulses. 7. A computer simulation, using a model cell in which an outward current with the kinetics and voltage dependence of the Kv3.1 channel was incorporated, also confirmed that the Kv3.1- like current is essential for cells to respond to a sustained train of high-frequency stimuli. 8. We conclude that in mouse MNTB neurones the Kv3.1 channel contributes to the ability of these cells to lock their firing to high-frequency inputs.

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Authors: Wang, L., Gan, L., Forsythe, I. D., & Kaczmarek, L. K.
Affiliations: Yale University (US)
University of Leicester (GB)
ORCID: Wang, Lu‐Yang
Gan, Li
Forsythe, Ian D.
Kaczmarek, Leonard K.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 1998-05
Volume: 509
Issue: 1
Pages: 183-194
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1111/j.1469-7793.1998.183bo.x
PMC: PMC2230948
OpenAlex: W1997293666
Cited by: 357
References: 39
Citations by year: 2026: 8 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 11 · 2016: 8 · 2015: 14 · 2014: 14 · 2013: 8 · 2012: 8
FWCI: 6.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2336 d)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion)
Funders: Wellcome Trust
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Kv3.1 potassium channel, high-frequency firing, auditory neurons, medial nucleus of the trapezoid body, tetraethylammonium, auditory brainstem
MeSH terms: Animals, Computer Simulation, Elapid Venoms, Electric Stimulation, Electrophysiology, Cricetinae, Kinetics, Membrane Potentials, Neurons, Pons, RNA, Messenger, Potassium Channels, CHO Cells, In Situ Hybridization, Patch-Clamp Techniques, Tetraethylammonium, Mice, In Vitro Techniques

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Contribution of the Kv3.1 potassium channel to high‐frequency firing in mouse auditory neurones

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