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Tetrodotoxin‐resistant impulses in single nociceptor nerve terminals in guinea‐pig cornea
Open accessAbstract
Extracellular recording techniques have been used to study nerve impulses in single sensory nerve terminals in guinea‐pig cornea isolated in vitro. Nerve impulses occurred spontaneously and were evoked by electrical stimulation of the ciliary nerves. The nerve impulses were identified as originating in polymodal receptors, mechano‐receptors or ‘cold’ receptors. All three types are believed to be nociceptors. Tetrodotoxin (TTX, 1 μ m) blocked nerve impulses evoked by electrical stimulation of the ciliary nerves. However, ongoing and/or naturally evoked nerve impulses persisted in the presence of TTX in all three types of receptors. Lignocaine (lidocaine; 1 m m) blocked all electrical activity. TTX‐resistant sodium channels therefore play a major role in generating the action potentials that signal pain to the brain.
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Cited by
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.4.581 · Cited by 3,392
The roles of sodium channels in nociception: Implications for mechanisms of pain
Cummins, T. R., Sheets, P. L., & Waxman, S. G. (2007) · Pain · doi:10.1016/j.pain.2007.07.026 · Cited by 485
Blair, N. T., & Bean, B. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10277.2002 · Cited by 426
Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons
Rush, A. M., Cummins, T. R., & Waxman, S. G. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.121483 · Cited by 425
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea
Parra, A., Madrid, R., Echevarria, D., del Olmo, S., Morenilla-Palao, C., Acosta, M. C., Gallar, J., Dhaka, A., Viana, F., & Belmonte, C. (2010) · Nature Medicine · doi:10.1038/nm.2264 · Cited by 324
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Metadata
- Authors
- Brock, J. A., McLachlan, E. M., & Belmonte, C.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1998-10
- Volume
- 512
- Issue
- 1
- Pages
- 211-217
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1992818845
- Cited by
- 209
- References
- 0
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brock, J. A., McLachlan, E. M., & Belmonte, C. (1998). Tetrodotoxin‐resistant impulses in single nociceptor nerve terminals in guinea‐pig cornea. The Journal of Physiology. https://doi.org/10.1111/j.1469-7793.1998.211bf.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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