The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men
Open accessAbstract
1. In experimental animals chronic elevations in arterial blood flow increase the lumen diameter and reduce the intima-media thickness (IMT) of the arterial segment involved. We determined whether intermittent elevations in active muscle blood flow associated with regular aerobic leg exercise induced such expansive arterial remodelling in the common femoral artery of humans. 2. In the cross-sectional study 53 sedentary (47 +/- 2 years) and 55 endurance exercise-trained (47 +/- 2 years) men were studied. Common femoral artery lumen diameter (B-mode ultrasound) was 7 % greater (9.62 +/- 0.12 vs. 9.03 +/- 0.13 mm), and femoral IMT (0.46 +/- 0.02 vs. 0.55 +/- 0.02 mm) and IMT/lumen ratio were 16-21 % smaller in the endurance-trained men (all P < 0.001). Basal femoral artery blood flow (duplex ultrasound) was not different, shear stress tended to be lower (P = 0.08), and mean femoral tangential wall stress was 30 % higher in the endurance-trained men (P < 0.001). 3. In the intervention study 22 men (51 +/- 2 years) were studied before and after 3 months of regular aerobic leg exercise (primarily walking). After training, the femoral diameter increased by 9 % (8.82 +/- 0.18 vs. 9.60 +/- 0.20 mm), and IMT (0.65 +/- 0.05 vs. 0.56 +/- 0.05 mm) and the IMT/lumen ratio were approximately 15-20 % smaller (all P < 0.001). Basal femoral blood flow and shear stress were not different after training, whereas the mean femoral tangential wall stress increased by 31 %. The changes in arterial structure were not related to changes in risk factors for atherosclerosis. 4. Our results are consistent with the concept that regular aerobic leg exercise induces expansive arterial remodelling in the femoral artery of healthy men. This adaptive process is produced by even a moderate training stimulus, is not obviously dependent on corresponding improvements in risk factors for atherosclerosis, and is robust, occurring in healthy men of different ages.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging.
Pignoli, P., Tremoli, E., Poli, A., Oreste, P., & Paoletti, R. (1986) · Circulation · doi:10.1161/01.cir.74.6.1399 · Cited by 2,404
Blair, S. N. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540030039029 · Cited by 1,819
Regular Physical Activity and Coronary Risk Factors in Japanese Men
Hsieh, S. D., Yoshinaga, H., Muto, T., & Sakurai, Y. (1998) · Circulation · doi:10.1161/01.cir.97.7.661 · Cited by 114
Cited by
Effect of exercise training on endothelium‐derived nitric oxide function in humans
Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068197 · Cited by 1,040
Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli
Green, D. J., Hopman, M. T. E., Padilla, J., Laughlin, M. H., & Thijssen, D. H. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00014.2016 · Cited by 821
Effects of exercise on vascular function, structure, and health in humans
Green, D. J., & Smith, K. J. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029819 · Cited by 197
Exercise Induces Tissue-Specific Adaptations to Enhance Cardiometabolic Health
Ashcroft, S. P., Stocks, B., Egan, B., & Zierath, J. R. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.008 · Cited by 149
Magnitude and Time Course of Arterial Vascular Adaptations to Inactivity in Humans
de Groot, P. C. E., Bleeker, M. W. P., & Hopman, M. T. E. (2006) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-200604000-00005 · Cited by 51
Metadata
- Authors
- Dinenno, F. A., Tanaka, H., Monahan, K. D., Clevenger, C. M., Eskurza, I., DeSouza, C. A., & Seals, D. R.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2001-07
- Volume
- 534
- Issue
- 1
- Pages
- 287-295
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2017430925
- Cited by
- 262
- References
- 3
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. https://app.cochat.ai/papers/10.1111/j.1469-7793.2001.00287.x
- The paper
- Dinenno, F. A., Tanaka, H., Monahan, K. D., Clevenger, C. M., Eskurza, I., DeSouza, C. A., & Seals, D. R. (2001). Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. The Journal of Physiology. https://doi.org/10.1111/j.1469-7793.2001.00287.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
