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Mismatch negativity (MMN), the deviance-elicited auditory deflection, explained
Abstract
The current review constitutes the first comprehensive look at the possibility that the mismatch negativity (MMN, the deflection of the auditory ERP/ERF elicited by stimulus change) might be generated by so-called fresh-afferent neuronal activity. This possibility has been repeatedly ruled out for the past 30 years, with the prevailing theoretical accounts relying on a memory-based explanation instead. We propose that the MMN is, in essence, a latency- and amplitude-modulated expression of the auditory N1 response, generated by fresh-afferent activity of cortical neurons that are under nonuniform levels of adaptation.
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In the citing paper
“As for the multi-standard control results, these arise from the cortical columns being interconnected rather than acting as isolated frequency channels.”
From The Adaptation Model Offers a Challenge for the Predictive Coding Account of Mismatch Negativity (2021) · cites this paper as May and Tiitinen, 2010
In the citing paper
“In addition, the omission response could be enhanced or even caused by high-pass filtering acting on the sudden, omission-related drop in the sustained activity which is elicited by fast-rate stimulation (May and Tiitinen, 2010).”
From The Adaptation Model Offers a Challenge for the Predictive Coding Account of Mismatch Negativity (2021) · cites this paper as May and Tiitinen, 2010
In the citing paper
“In the adaptation hypothesis, as neuronal responses to standard stimuli decline after repetitive presentation of standard stimuli (11), MMN is thought to represent the difference between intact neural responses to deviant stimuli and attenuated neural responses to standard stimuli.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [10]
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Self-citationAtienza, M., Cantero, J. L., & Gómez, C. M. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(00)00196-3 · Cited by 16
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Left-hemispheric brain activity reflects formant transitions in speech sounds
kel, A. M. M., Alku, P., May, P., et al. (2005) · Neuroreport · doi:10.1097/00001756-200504250-00006 · Cited by 13
Self-citationRate of stimulation affects schizophrenia-normal differences on the N1 auditory-evoked potential.
Gilmore, C. S., Clementz, B. A., & Buckley, P. F. (2004) · PubMed · Cited by 13
A Comparison of the mismatch negativity and a differential waveform response
Elangovan, S., Cranford, J. L., Walker, L. J., & Stuart, A. (2005) · International Journal of Audiology · doi:10.1080/00222930500271564 · Cited by 12
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Auditory scene analysis and sensory memory: the role of the auditory N100m.
May, P., & Tiitinen, H. (2004) · PubMed · Cited by 12
Self-citationAttention and evoked otoacoustic emissions: attempts at characterization of intersubject variation
Meric, C., Micheyl, C., & Collet, L. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02008-x · Cited by 11
Early Event-Related Potentials with Passive Subject Participation
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Averaged and single-trial brain responses in the assessment of human sound detection
Tiitinen, H., kinen, V. M., Kičić, D., & May, P. (2005) · Neuroreport · doi:10.1097/00001756-200504250-00005 · Cited by 10
Self-citationMultiple neural origins of early auditory evoked potential of rat
Takahashi, H., Nakao, M., & Kaga, K. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.023 · Cited by 9
Auditory recovery cycle dysfunction in schizophrenia: A study using event-related potentials
Clunas, N. J., & Ward, P. B. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2005.05.009 · Cited by 8
Abnormality of mismatch negativity in response to tone omission in dyslexic adults
Fisher, A. E., Barnes, G. R., Hillebrand, A., Holliday, I. E., Witton, C., & Richards, I. L. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.121 · Cited by 8
Okamoto, H., Stracke, H., & Pantev, C. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.11.038 · Cited by 6
Periodic glottal excitation and formant frequencies in the perception of vowels.
Tiitinen, H., Mäkelä, A.-M., Mäkinen, V. T., et al. (2004) · PubMed · Cited by 5
Self-citationBehavioral detection of spatial stimuli is reflected in auditory cortical dynamics.
Tiitinen, H., Palomäki, K. J., Mäkinen, V. T., et al. (2004) · PubMed · Cited by 4
Self-citationThe effects of aging on the processing of rising-intensity tonal and speech stimuli
Tiitinen, H., Matilainen, L. E., Talvitie, S. S., et al. (2007) · International Congress Series · doi:10.1016/j.ics.2007.01.015 · Cited by 3
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Talvitie, S. S., Matilainen, L. E., Pekkonen, E., et al. (2007) · International Congress Series · doi:10.1016/j.ics.2007.03.027 · Cited by 3
Leino, S., May, P., Alku, P., et al. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-78 · Cited by 2
Self-citationThe auditory n100m response reflects changes in speech fundamental frequency.
Mäkelä, A.-M., Alku, P., May, P., et al. (2004) · PubMed · Cited by 2
Self-citationCortical activity elicited by isolated vowels and diphthongs.
Mäkelä, A. M., Alku, P., May, P., et al. (2004) · PubMed · Cited by 2
Self-citationMemory traces in human auditory cortex
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Precise minds in uncertain worlds: Predictive coding in autism.
Van de Cruys, S., Evers, K., Van der Hallen, R., Van Eylen, L., Boets, B., de-Wit, L., & Wagemans, J. (2014) · Psychological Review · doi:10.1037/a0037665 · Cited by 885
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Metadata
- Authors
- May, P. J. C., & Tiitinen, H.
- Affiliations
- Aalto University (FI)
- Corresponding author
- May, Patrick J. C.
- ORCID
- May, Patrick J. C.
- Venue
- Psychophysiology
- Publisher
- Wiley
- Published
- 2010-01
- Volume
- 47
- Issue
- 1
- Pages
- 66-122
- ISSN
- 0048-5772 (ISSN-L)
- 1469-8986
- OpenAlex
- W2119845553
- Cited by
- 549
- References
- 537
- Citations by year
- 2026: 29 · 2025: 27 · 2024: 19 · 2023: 27 · 2022: 33 · 2021: 23 · 2020: 42 · 2019: 35 · 2018: 24 · 2017: 30 · 2016: 29 · 2015: 42 · 2014: 45 · 2013: 53 · 2012: 29
- FWCI
- 14.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- mismatch negativity, auditory event-related potentials, deviance, sensory adaptation, memory-based models, cortical neurons
- MeSH terms
- Acoustic Stimulation, Adaptation, Psychological, Affect, Auditory Cortex, Auditory Perception, Auditory Threshold, Electroencephalography, Evoked Potentials, Auditory, Humans, Memory, Neuronal Plasticity
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