Localization of asymmetric brain function in emotion and depression
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Although numerous EEG studies have shown that depression is associated with abnormal functional asymmetries in frontal cortex, fMRI and PET studies have largely failed to identify specific brain areas showing this effect. The present study tested the hypothesis that emotion processes are related to asymmetric patterns of fMRI activity, particularly within dorsolateral prefrontal cortex (DLPFC). Eleven depressed and 18 control participants identified the color in which pleasant, neutral, and unpleasant words were printed. Both groups showed a leftward lateralization for pleasant words in DLPFC. In a neighboring DLPFC area, the depression group showed more right-lateralized activation than controls, replicating EEG findings. These data confirm that emotional stimulus processing and trait depression are associated with asymmetric brain functions in distinct subregions of the DLPFC that may go undetected unless appropriate analytic procedures are used.
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Individuals with depression commonly show abnormal brain activity in regions thought to implement executive function.
“For example, individuals with depression commonly exhibit abnormal brain activity in brain regions purported to implement EF (Engels et al. 2010; Herrington et al. 2010; Warren et al. 2013).”
From Executive Function Deficits in Daily Life Prospectively Predict Increases in Depressive Symptoms (2014) · cites this paper as Herrington et al. 2010
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References 144 · Cited by 169
- Authors
- Herrington, J. D., Heller, W., Mohanty, A., Engels, A. S., Banich, M. T., Webb, A. G., & Miller, G. A.
- Affiliations
- Children's Hospital of Philadelphia (US)
- University of Illinois Urbana-Champaign (US)
- Northwestern University (US)
- Pennsylvania State University (US)
- University of Colorado Boulder (US)
- Corresponding author
- Herrington, John D.
- ORCID
- Venue
- Psychophysiology
- Publisher
- Wiley
- Published
- 2010-05
- Volume
- 47
- Issue
- 3
- Pages
- 442-454
- ISSN
- 0048-5772 (ISSN-L)
- 1469-8986
- PMC
- PMC3086589
- OpenAlex
- W2109173893
- Cited by
- 169
- References
- 144
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 14 · 2018: 8 · 2017: 11 · 2016: 9 · 2015: 8 · 2014: 23 · 2013: 10 · 2012: 16
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01 MH-61358, P50MH079485, T32MH019554, T32 MH-19554, R01MH061358)
- National Institute on Drug Abuse (R21DA014111, R21 DA 14111)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, emotional word processing, hemispheric lateralization, dorsolateral prefrontal cortex, brain asymmetry, trait depression, emotional valence, functional MRI
- MeSH terms
- Affect, Amygdala, Brain, Data Interpretation, Statistical, Depression, Electroencephalography, Emotions, Female, Frontal Lobe, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Motivation, Neuropsychological Tests, Psychomotor Performance, Young Adult
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