The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer
Abstract
Summary. Age, ultrasound score, menopausal status, a clinical impression score and serum CA 125 level were assessed to see how they could best distinguish between patients with benign (n = 101) and malignant (n – 42) pelvic masses. Each criteria used alone provided statistically significant discrimination. The most useful individual criteria were a serum CA 125 level of 30 U/ml (sensitivity 81 %, specificity 75%) and an ultrasound score of 2 (sensitivity 71%, specificity 83%). Three criteria could be combined in a risk of malignancy index (RMI) which is simply calculated using the product of the serum CA 125 level (U/ml), the ultrasound scan result (expressed as a score of 0, 1 or 3) and the menopausal status (1 if premenopausal and 3 if postmenopausal). This index was statistically virtually as effective a discriminant between cancer and benign lesions as more formal methods. Using an RMI cut‐off level of 200, the sensitivity was 85% and the specificity was 97%. Patients with an RMT score of greater than 200 had, on average, 42 times the background risk of cancer and those with a lower value 0.15 times the background risk.
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Cites
The CA 125 tumour-associated antigen: a review of the literature
Jacobs, I., & Bast, R. C. (1989) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136832 · Cited by 955
Self-citationTransvaginal colour flow imaging: a possible new screening technique for ovarian cancer.
Bourne, T., Campbell, S., Steer, C., Whitehead, M. I., & Collins, W. P. (1989) · BMJ · doi:10.1136/bmj.299.6712.1367 · Cited by 301
MULTIMODAL APPROACH TO SCREENING FOR OVARIAN CANCER
Jacobs, I., Bridges, J., Reynolds, C., Stabile, I., Kemsley, P., Grudzinskas, J., & Oram, D. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90351-0 · Cited by 241
Self-citationMalkasian, G. D., Knapp, R. C., Lavin, P. T., Zurawski, V. R., Podratz, K. C., Stanhope, C. R., Mortel, R., Berek, J. S., Bast, R. C., & Ritts, R. E. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(88)80081-4 · Cited by 227
Serum CA 125 levels in preoperative evaluation of pelvic masses.
Vasilev, S. A., Schlaerth, J. B., Campeau, J., & Morrow, C. P. (1988) · PubMed · Cited by 134
Cited by
Van Calster, B., Van Hoorde, K., Valentin, L., Testa, A. C., Fischerova, D., Van Holsbeke, C., Savelli, L., Franchi, D., Epstein, E., Kaijser, J., et al. (2014) · BMJ · doi:10.1136/bmj.g5920 · Cited by 510
(2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1174 · Cited by 276
ESGO/ISUOG/IOTA/ESGE Consensus Statement on preoperative diagnosis of ovarian tumors
Timmerman, D., Planchamp, F., Bourne, T., Landolfo, C., du Bois, A., Chiva, L., Cibula, D., Concin, N., Fischerova, D., Froyman, W., et al. (2021) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.23635 · Cited by 114
Amor, F., Vaccaro, H., Alcázar, J. L., León, M., Craig, J. M., & Martinez, J. (2009) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2009.28.3.285 · Cited by 98
External Validation of Diagnostic Models to Estimate the Risk of Malignancy in Adnexal Masses
Van Holsbeke, C., Van Calster, B., Bourne, T., Ajossa, S., Testa, A. C., Guerriero, S., Fruscio, R., Lissoni, A. A., Czekierdowski, A., Savelli, L., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0879 · Cited by 87
Metadata
- Authors
- JACOBS, I., ORAM, D., FAIRBANKS, J., TURNER, J., FROST, C., & GRUDZINSKAS, J. G.
- Venue
- BJOG: An International Journal of Obstetrics & Gynaecology
- Publisher
- Wiley
- Published
- 1990-10
- Volume
- 97
- Issue
- 10
- Pages
- 922-929
- ISSN
- 0306-5456 (ISSN-L)
- 1470-0328
- 1471-0528
- OpenAlex
- W2126233390
- Cited by
- 962
- References
- 5
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer. https://app.cochat.ai/papers/10.1111/j.1471-0528.1990.tb02448.x
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- JACOBS, I., ORAM, D., FAIRBANKS, J., TURNER, J., FROST, C., & GRUDZINSKAS, J. G. (1990). A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer. BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/j.1471-0528.1990.tb02448.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
