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Cited by 30Congenital Diaphragmatic Hernia StudiesNeonatal Respiratory Health ResearchCongenital Anomalies and Fetal Surgery

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Three-dimensional ultrasound fetal lung volumes and infant respiratory outcome: a prospective observational study

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Prendergast, M, Rafferty, GF, Davenport, M, Persico, N, Jani, J, Nicolaides, K, Greenough, A·2011·BJOG: An International Journal of Obstetrics & Gynaecology
DOI 10.1111/j.1471-0528.2010.02841.x
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Abstract

OBJECTIVE: To determine if fetal lung volumes (FLVs), determined by three-dimensional rotational ultrasound and virtual organ computer-aided analysis software (vocal), correlated with neonatal respiratory outcomes in surviving infants who had a high risk [fetuses with congenital diaphragmatic hernia (CDH)], lower risk [fetuses with anterior wall defects (AWDs)] and no risk (controls) of abnormal antenatal lung growth. DESIGN: Prospective observational study. SETTING: Tertiary fetal medicine and neonatal intensive care units. POPULATION: Sixty fetuses (25 with CDH, 25 with AWDs and ten controls). METHODS: FLVs were measured and expressed as the percentage of the observed compared with the expected for gestational age. MAIN OUTCOME MEASURES: Neonatal respiratory outcome was determined by the duration of supplemental oxygen, mechanical ventilation and dependencies, and assessment of lung volume using a gas dilution technique to measure functional residual capacity (FRC). RESULTS: The infants with CDH had lower FLV results than both the infants with AWDs (P=0.05) and the controls (P<0.05). The infants with CDH had longer durations of mechanical ventilation (P<0.001) and supplementary oxygen (P<0.001) dependence, compared with infants with AWDs. The infants with CDH had a lower median FRC than both the infants with AWDs (P<0.001) and the controls (P<0.001). FLV results correlated significantly with the durations of dependency on ventilation (r= -0.744, P<0.01) and oxygen (r= -0.788, P<0.001), and with FRC results (r=0.429, P=0.001). CONCLUSIONS: These results suggest that FLVs obtained using three-dimensional rotational ultrasound might be useful in predicting neonatal respiratory outcome in surviving infants who had varying risks of abnormal lung growth. Larger and more comprehensive studies are needed to clarify the role that lung volume measurements have in assessing lung function and growth.

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Metadata

Authors
Prendergast, M., Rafferty, G., Davenport, M., Persico, N., Jani, J., Nicolaides, K., & Greenough, A.
Affiliations
  • King's College London (GB)
  • King's College Hospital (GB)
  • Centre Hospitalier Universitaire Brugmann (BE)
Corresponding author
Greenough, A
ORCID
Venue
BJOG: An International Journal of Obstetrics & Gynaecology
Publisher
Wiley
Published
2011-02-04
Volume
118
Issue
5
Pages
608-614
ISSN
  • 0306-5456 (ISSN-L)
  • 1470-0328
DOI
10.1111/j.1471-0528.2010.02841.x
OpenAlex
W1825849392
Cited by
30
References
0
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 3
FWCI
3.92
Type
journal article
Language
en
Open access
Licence
Locations
  • BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, other-oa)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Congenital Diaphragmatic Hernia Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
  • Health Sciences › Medicine › Surgery › Congenital Anomalies and Fetal Surgery
Keywords
fetal lung volume, congenital diaphragmatic hernia, neonatal respiratory outcomes, functional residual capacity, mechanical ventilation, fetal lung function
MeSH terms
Birth Weight, Female, Functional Residual Capacity, Gestational Age, Hernia, Diaphragmatic, Humans, Hyperplasia, Infant, Infant, Newborn, Lung, Male, Pregnancy, Prognosis, Prospective Studies, Respiration Disorders, Ultrasonography, Prenatal, Imaging, Three-Dimensional, Hernias, Diaphragmatic, Congenital

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