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Regional Accumulation of Calcium in Postischemic Rat Brain
Abstract
Abstract: The regional concentrations of intravenously injected 45 Ca and total calcium were measured in rat brain during recovery from transient occlusion of the four major arteries to the brain. 45 Ca was injected at intervals after ischemia, and the regional distribution of 45 Ca was estimated by autoradiography. The 45 Ca appeared to enter the brain via the choroid plexus, labeling the paraventricular tissue at 1 h after the injection. Control brains had more 45 Ca in the gray matter compared to fiber‐rich areas at 5 and 24 h, but within these regions the optical density was nearly uniform. The accumulation and retention of 45 Ca in postischemic brain were selective and time‐dependent. The regional pattern of 45 Ca uptake correlated with the temporal progression of ischemic cell change. Infarction and preischemic hyperglycemia increased morphological damage, and increased the extent and distribution of 45 Ca accumulation. The rise in total calcium concentration appeared to be biphasic in irreversibly damaged tissue.
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Cited by
Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage
Choi, D. W. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90200-7 · Cited by 1,736
Selective vulnerability of the hippocampus in brain ischemia
Schmidt-Kastner, R., & Freund, T. F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90001-5 · Cited by 888
Calcium in Ischemic Cell Death
Kristián, T., & Siesjö, B. K. (1998) · Stroke · doi:10.1161/01.str.29.3.705 · Cited by 825
The role of calcium in apoptosis
Nicotera, P., & Orrenius, S. (1998) · Cell Calcium · doi:10.1016/s0143-4160(98)90116-6 · Cited by 458
Historical Overview: Calcium, Ischemia, and Death of Brain Cellsa
SIESJÖ, B. K. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb33410.x · Cited by 422
Metadata
- Authors
- Dienel, G. A.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1984-10
- Volume
- 43
- Issue
- 4
- Pages
- 913-925
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2025627786
- Cited by
- 319
- References
- 0
- FWCI
- 12.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dienel, G. A. (1984). Regional Accumulation of Calcium in Postischemic Rat Brain. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1984.tb12825.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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