The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Presence of Kynurenic Acid in the Mammalian Brain
Abstract
Kynurenic acid, a tryptophan metabolite able to antagonize the actions of the excitatory amino acids, has been identified and measured for the first time in the brain of mice, rats, guinea pigs, and humans by using an HPLC method. Its content was 5.8 ± 0.9 in mouse brain, 17.8 ± 2.0 in rat brain, 16.2 ± 1.5 in guinea pig brain, 26.8 ± 2.9 in rabbit brain, and 150 ± 30 in human cortex (pmol/g wet wt, mean ± SE). The regional distribution of this molecule was uneven. In rats, guinea pigs, and rabbits, the brainstem was the area richest in this compound. Tryptophan administration (100–300 mg/kg, i.p.) to rats resulted in a significant increase of the brain content of kynurenic acid. Similarly, 1 h after probenecid administration (200 mg/kg, i.p.), the brain content of kynurenate increased by fourfold, thus suggesting that its turnover rate is relatively fast.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Glowinski, J., & Iversen, L. L. (1966) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1966.tb09873.x · Cited by 5,406
Perkins, M. N., & Stone, T. W. (1982) · Brain Research · doi:10.1016/0006-8993(82)91048-4 · Cited by 849
Foster, A. C., Vezzani, A., French, E. D., & Schwarcz, R. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90050-8 · Cited by 434
Neef, N. H., Tozer, T. N., & Brodie, B. B. (1967) · PubMed · Cited by 306
Quinolinic acid and other kynurenines in the central nervous system
Stone, T. W., & Connick, J. H. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90063-6 · Cited by 304
SYNTHESIS AND METABOLISM OF l‐KYNURENINE IN RAT BRAIN
Gál, E. M., & Sherman, A. D. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb07815.x · Cited by 177
Jahr, C., & Jessell, T. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-08-02281.1985 · Cited by 172
Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate.
Hirata, F., & Hayaishi, O. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41144-7 · Cited by 169
Identification and Distribution of Tryptamine in the Rat
Philips, S. R., Burden, D. A., & Boulton, A. A. (1974) · Canadian Journal of Biochemistry · doi:10.1139/o74-068 · Cited by 136
The excitotoxin quinolinic acid is present and unevenly distributed in the rat brain
Moroni, F., Lombardi, G., Carla�, V., & Moneti, G. (1984) · Brain Research · doi:10.1016/0006-8993(84)90984-3 · Cited by 131
Self-citation
Cited by
Kynurenines in the mammalian brain: when physiology meets pathology
Schwarcz, R., Bruno, J. P., Muchowski, P. J., & Wu, H.-Q. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3257 · Cited by 1,530
Danysz, W., & Parsons, C. G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01382-6 · Cited by 649
Increased cortical kynurenate content in schizophrenia
Schwarcz, R., Rassoulpour, A., Wu, H.-Q., Medoff, D., Tamminga, C. A., & Roberts, R. C. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01078-2 · Cited by 590
Tryptophan metabolism and gut-brain homeostasis
Roth, W., Zadeh, K., Vekariya, R., Ge, Y., & Mohamadzadeh, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062973 · Cited by 519
Metadata
- Authors
- Moroni, F., Russi, P., Lombardi, G., Beni, M., & Carlà, V.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1988-07
- Volume
- 51
- Issue
- 1
- Pages
- 177-180
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1985118788
- Cited by
- 278
- References
- 17
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Presence of Kynurenic Acid in the Mammalian Brain. https://app.cochat.ai/papers/10.1111/j.1471-4159.1988.tb04852.x
- The paper
- Moroni, F., Russi, P., Lombardi, G., Beni, M., & Carlà, V. (1988). Presence of Kynurenic Acid in the Mammalian Brain. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1988.tb04852.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
