The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism
Abstract
Abstract: The effects of 1‐methyl‐4‐phenylpyridinium (MPP+) were studied in rat striatum. Using freeze‐clamp, microwave, and water‐suppressed proton chemical shift magnetic resonance imaging techniques, MPP+ resulted in marked increases in lactate and a depletion of ATP for up to 48 h after the injections. MPP+ produced dose‐dependent depletions of dopamine, serotonin, γ‐aminobutyric acid, and substance P that were partially blocked at 1 week by prior decortication or completely blocked by MK‐801 at 24 h. The lesions showed relative sparing of somatostatin‐neuropeptide Y neurons, consistent with N‐methyl‐D‐aspartate (NMDA) excitotoxicity. MPP+ produces impairment of oxidative phosphorylation in vivo, which may result in membrane depolarization with persistent activation of NMDA receptors and excitotoxic neuronal degeneration. An impairment of energy metabolism may therefore underlie slow excitotoxic neuronal death in neurodegenerative diseases.
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Cites
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
Trounce, I., Byrne, E., & Marzuki, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92143-0 · Cited by 730
Cited by
Blum, D., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A.-L., Sadoul, R., & Verna, J.-M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246
The Role of Excitotoxicity in Neurodegenerative Disease
Doble, A. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723
Przedborski, S., Jackson‐Lewis, V., Naini, A. B., Jakowec, M., Petzinger, G., Miller, R., & Akram, M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00183.x · Cited by 507
Gerlach, M., & Riederer, P. (1996) · Journal of Neural Transmission · doi:10.1007/bf01291788 · Cited by 498
Cubells, J., Rayport, S., Rajendran, G., & Sulzer, D. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02260.1994 · Cited by 448
Metadata
- Authors
- Storey, E., Hyman, B. T., Jenkins, B., Brouillet, E., Miller, J. M., Rosen, B. R., & Beal, M. F.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1992-05
- Volume
- 58
- Issue
- 5
- Pages
- 1975-1978
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2150648464
- Cited by
- 164
- References
- 1
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism. https://app.cochat.ai/papers/10.1111/j.1471-4159.1992.tb10080.x
- The paper
- Storey, E., Hyman, B. T., Jenkins, B., Brouillet, E., Miller, J. M., Rosen, B. R., & Beal, M. F. (1992). 1‐Methyl‐4‐Phenylpyridinium Produces Excitotoxic Lesions in Rat Striatum as a Result of Impairment of Oxidative Metabolism. Journal of Neurochemistry. https://doi.org/10.1111/j.1471-4159.1992.tb10080.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
