The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
5‐Hydroxytryptamine Receptors
Abstract
5‐Hydroxytryptamine (5‐HT) receptors consist of at least three distinct types of molecular structures (Table 1): guanine nucleotide binding protein (G protein)‐coupled receptors, ligand‐gated ion channels, and transporters. Prior to the introduction of molecular biological techniques, the classification of 5‐HT receptors was based predominantly on the pharmacological properties of the receptors. For example, “5‐HT 1” receptors were defined as membrane binding sites that displayed nanomolar affinity for [3 H]5‐HT (Peroutka and Snyder, 1979). Subsequently, Bradley et al. (1986) defined “5‐HT 1‐like” receptors by their susceptibility to antagonism by methiothepin and/or methysergide, resistance to antagonism by 5‐HT 2 antagonists, and potent agonism by 5‐carboxamidotryptamine (5‐CT). Thus, these classification systems are dependent upon the availability of selective pharmacological agents.
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Pazos, A., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855
PEROUTKA, S. J., & SNYDER, S. H. (1979) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13812-1 · Cited by 1,360
Self-citationProposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., & Saxena, P. R. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90207-8 · Cited by 1,258
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
Maricq, A. V., Peterson, A. S., Brake, A. J., Myers, R. M., & Julius, D. (1991) · Science · doi:10.1126/science.1718042 · Cited by 979
Cloning and expression of a functional serotonin transporter from rat brain
Blakely, R. D., Berson, H. E., Fremeau, R. T., Caron, M. G., Peek, M. M., Prince, H. K., & Bradley, C. C. (1991) · Nature · doi:10.1038/354066a0 · Cited by 831
Pazos, A., Cortés, R., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90857-1 · Cited by 824
Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT
Gozlan, H., El Mestikawy, S., Pichat, L., Glowinski, J., & Hamon, M. (1983) · Nature · doi:10.1038/305140a0 · Cited by 758
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
Julius, D., MacDermott, A. B., Axel, R., & Jessell, T. M. (1988) · Science · doi:10.1126/science.3399891 · Cited by 694
Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family
Libert, F., Parmentier, M., Lefort, A., Dinsart, C., Van Sande, J., Maenhaut, C., Simons, M.-J., Dumont, J. E., & Vassart, G. (1989) · Science · doi:10.1126/science.2541503 · Cited by 641
Cloning of a Serotonin Transporter Affected by Antidepressants
Hoffman, B. J., Mezey, E., & Brownstein, M. J. (1991) · Science · doi:10.1126/science.1948036 · Cited by 611
Cited by
Neurotransmitter regulation of dopamine neurons in the ventral tegmental area
Kalivas, P. W. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90008-n · Cited by 708
Molecular biology of 5-HT receptors
Boess, F. G., & Martin, I. L. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90059-0 · Cited by 677
Effects of Moderate Alcohol Consumption on the Central Nervous System*
Eckardt, M. J., File, S. E., Gessa, G. L., Grant, K. A., Guerri, C., Hoffman, P. L., Kalant, H., Koob, G. F., Li, T., & Tabakoff, B. (1998) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03695.x · Cited by 622
Mechanism of action of serotonin selective reuptake inhibitors
Stahl, S. M. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00221-3 · Cited by 540
Multiplicity of mechanisms of serotonin receptor signal transduction
Raymond, J. R., Mukhin, Y. V., Gelasco, A., Turner, J., Collinsworth, G., Gettys, T. W., Grewal, J. S., & Garnovskaya, M. N. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00169-3 · Cited by 466
Metadata
- Authors
- Peroutka, S. J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1993-02
- Volume
- 60
- Issue
- 2
- Pages
- 408-416
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1975429926
- Cited by
- 521
- References
- 54
- FWCI
- 21.11
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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