Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

Poirier, Steve; Prat, Annik; Marcinkiewicz, Edwige; Paquin, Joanne; Chitramuthu, Babykumari P.; Baranowski, David; Cadieux, Benoit; Bennett, Hugh P. J.; Seidah, Nabil G.

doi:10.1111/j.1471-4159.2006.03928.x

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

Neural apoptosis-regulated convertase-1/proprotein convertase subtilisin-kexin like-9 (NARC-1/PCSK9) is a proprotein convertase recently described to play a major role in cholesterol homeostasis through enhanced degradation of the low-density lipoprotein receptor (LDLR) and possibly in neural dev…