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Cited by 249Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity: TAAR1 regulation of monoaminergic activity

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Miller, Gregory M.·2011·Journal of Neurochemistry
DOI 10.1111/j.1471-4159.2010.07109.xPMC PMC3005101
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Abstract

It is now recognized that trace amine associated-receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants. Accordingly, research on TAAR1 opens the door to a new avenue of approach for medications development to treat drug addiction as well as the spectrum of neuropsychiatric disorders hallmarked by aberrant regulation of brain monoamines. This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity.

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  • LDX can promote the increase of DA in the synaptic cleft by activating TAAR1, which produces the efflux of monoamine NTs, mainly DA, from storage sites on presynaptic neurons.

    “LDX can also promote the increase of DA in the synaptic cleft by activating protein TAAR1, which produces the efflux of monoamine NTs, mainly DA, from storage sites on presynaptic neurons [155, 177].”

    From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [177]

    The section “TAAR1-mediated effects are phosphorylation dependent” reports TAAR1-mediated dopamine efflux in response to methamphetamine in cells and mouse striatal synaptosomes. The copy does not establish that LDX itself activates TAAR1, that dopamine is the main monoamine released by LDX, or that the efflux originates from presynaptic storage sites. A search for “lisdexamfetamine” found no passage addressing it; no page numbers were provided. (LLM, conf=0.85)

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Authors
Miller, G. M.
Affiliations
Harvard University (US)
Corresponding author
Miller, Gregory M.
ORCID
Miller, Gregory M.
Venue
Journal of Neurochemistry
Publisher
Wiley
Published
2010-12-16
Volume
116
Issue
2
Pages
164-176
ISSN
0022-3042 (ISSN-L)
DOI
10.1111/j.1471-4159.2010.07109.x
PMC
PMC3005101
OpenAlex
W1608568575
Cited by
249
References
0
Citations by year
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FWCI
0.75
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1720 d)
Locations
  • Journal of Neurochemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Drug Abuse (K02DA025697, DA025697)
  • National Center for Research Resources (RR00 168, K26RR000168, P51RR000168)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
TAAR1, monoamine transporters, dopaminergic activity, drug addiction, neuropsychiatric disorders, brain monoamines, neurotransmitter modulation
MeSH terms
Trace Amine-Associated Receptors, Animals, Dopamine, Humans, Signal Transduction, Receptors, G-Protein-Coupled, Vesicular Monoamine Transport Proteins, Rats

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