The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
Open accessAbstract
Summary: The sirtuin family of nicotinamide adenine dinucleotide‐dependant (NAD) deacetylases plays an important role in aging and metabolic regulation. In yeast, the Sir2 gene and its homolog Hst2 independently mediate the action of caloric restriction on lifespan extension. The mammalian Sir2 ortholog, SIRT1, is up‐regulated by caloric restriction and deacetylates a variety of substrates, including histones and the forkhead box O (FOXO) transcription factors. The mammalian ortholog of Hst2, SIRT2, was shown to co‐localize with microtubules and functions as α‐tubulin deacetylase. During G2/M phase, SIRT2 proteins enter nuclei and deacetylate histones. We report here that the expression of SIRT2 is elevated in the white adipose tissue and kidney of caloric‐restricted mice. Oxidative stress, such as hydrogen peroxide treatment, also increases SIRT2 expression in cells. We have demonstrated that SIRT2 binds to FOXO3a and reduces its acetylation level. SIRT2 hence increases FOXO DNA binding and elevates the expression of FOXO target genes, p27 Kip1, manganese superoxide dismutase and Bim. As a consequence, SIRT2 decreases cellular levels of reactive oxygen species. Furthermore, as Bim is a pro‐apoptotic factor, SIRT2 promotes cell death when cells are under severe stress. Therefore, mammalian SIRT2 responds to caloric restriction and oxidative stress to deacetylate FOXO transcription factors.
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Cites
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Cited by
Calnan, D. R., & Brunet, A. (2008) · Oncogene · doi:10.1038/onc.2008.21 · Cited by 1,170
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Redox regulation of FoxO transcription factors
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Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
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Critical role of FOXO3a in carcinogenesis
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Metadata
- Authors
- Wang, F., Nguyen, M., Qin, F. X., & Tong, Q.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2007-04-18
- Volume
- 6
- Issue
- 4
- Pages
- 505-514
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W1968132748
- Cited by
- 655
- References
- 51
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, F., Nguyen, M., Qin, F. X., & Tong, Q. (2007). SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell. https://doi.org/10.1111/j.1474-9726.2007.00304.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
