Cited by 102Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsPluripotent Stem Cells Research

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Cellular lifespan and senescence signaling in embryonic stem cells

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Miura, Takumi, Mattson, Mark P., Rao, Mahendra S.·2004·Aging Cell

DOI 10.1111/j.1474-9728.2004.00134.x

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Abstract

Summary: Most mammalian cells when placed in culture will undergo a limited number of cell divisions before entering an unresponsive non‐proliferating state termed senescence. However, several pathways that are activated singly or in concert can allow cells to bypass senescence at least for limited periods. These include the telomerase pathway required to maintain telomere ends, the p53 and Rb pathways required to direct senescence in response to DNA damage, telomere shortening and mitogenic signals, and the insulin‐like growth factor – Akt pathway that may regulate lifespan and cell proliferation. In this review, we summarize recent findings related to these pathways in embryonic stem (ES) cells and suggest that ES cells are immortal because these pathways are tightly regulated.

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Authors: Miura, T., Mattson, M. P., & Rao, M. S.
Affiliations: National Institute on Aging (US)
Johns Hopkins University (US)
Corresponding author: Rao, Mahendra S.
ORCID: Mattson, Mark P.
Venue: Aging Cell
Publisher: Wiley
Published: 2004-11
Volume: 3
Issue: 6
Pages: 333-343
ISSN: 1474-9718 (ISSN-L)
1474-9726
DOI: 10.1111/j.1474-9728.2004.00134.x
OpenAlex: W1591789003
Cited by: 102
References: 130
Citations by year: 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2018: 9 · 2017: 4 · 2016: 3 · 2014: 7 · 2013: 10 · 2012: 7
FWCI: 0.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Aging Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: cellular senescence, embryonic stem cells, cellular lifespan, telomerase, telomere shortening, p53 pathway, Rb pathway, DNA damage response, insulin-like growth factor, Akt signaling, cell proliferation, cell immortalization
MeSH terms: Embryo, Mammalian, Humans, Models, Biological, Stem Cells, Signal Transduction, Cellular Senescence

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Cellular lifespan and senescence signaling in embryonic stem cells

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