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pAx AND COMPETITIVE DRUG ANTAGONISM
Open accessAbstract
In a recent paper Guarino and Bovet (1949) have studied the use of the measure pA for expressing intensity of drug antagonism.pA, has been defined (Schild, 1947) as the negative logarithm of the molar concentration of an antagonist which reduces the effect of a multiple dose, x, of a stimulant drug to that of a single dose.Guarino and Bovet have pointed out that this definition does not specify concentration of active drug, and therefore by implication assumes that pA is independent of the initial concentration of active drug used.In studying the an.-TYPE tagonism between acetylcholine coo and flaxedil* on the frog's rectus abdominis, however, they found that pA was not % , entirely independent of the CONTRACTION /
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Hodgson, R. A., Mullins, D., Lu, S. X., Guzzi, M., Zhang, X., Bleickardt, C. J., Scott, J. D., Miller, M. W., Stamford, A. W., Parker, E. M., et al. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.02.027 · Cited by 30
Metadata
- Authors
- SCHILD, H. O.
- Venue
- British Journal of Pharmacology and Chemotherapy
- Publisher
- Wiley
- Published
- 1949-09
- Volume
- 4
- Issue
- 3
- Pages
- 277-280
- ISSN
- 0366-0826 (ISSN-L)
- OpenAlex
- W2067586008
- Cited by
- 246
- References
- 0
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
