HISTAMINE AND 5‐HYDROXYTRYPTAMINE IN THE INTESTINAL TRACT OF GERM‐FREE ANIMALS, ANIMALS HARBOURING ONE MICROBIAL SPECIES AND CONVENTIONAL ANIMALS
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Histamine and 5‐hydroxytryptamine were determined in the intestinal tract of germ‐free and conventional rats and mice. Comparable histamine data were collected in Clostridium perfringens mono‐associated rats, while 5‐hydroxytryptamine determinations were extended to include the chicken. In rats and mice harbouring an intestinal microflora, bacterial formation of histamine occurs mainly in the caecum. Compared to values found in germ‐free animals, histamine levels in the wall of the small intestine of the conventional animal tend to be higher, though in the rat the data are not consistent. Mono‐association (harbouring of one microbial species) of germ‐free rats with a histamine‐producing strain of Clostridium perfringens resulted in high histamine concentrations in the caecal contents, but failed to increase the histamine levels in the wall of the small intestine. 5‐Hydroxytryptamine levels in the intestinal wall in the presence of an intestinal flora were generally lower than those in germ‐free animals. Modification of the flora by dietary administration of penicillin to mice partly abolished its depressing effect.
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C. perfringens, a member of the human and rodent microbiota, modulates gut production of 5-HT.
“Indeed, it has been long appreciated that the bacterial species C. perfringens, a member of the human and rodent microbiota, modulates gut production of 5-HT (Beaver and Wostmann, 1962).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Beaver and Wostmann, 1962
The paper reports lower intestinal-wall 5-hydroxytryptamine (5-HT) levels in rats and mice with an intestinal flora than in germ-free animals (5-Hydroxytryptamine in the wall of the gastro-intestinal tract; page unavailable). But its C. perfringens mono-association experiment measured histamine, not 5-HT, so it does not establish that this species modulates gut 5-HT production. The passages also do not establish that C. perfringens is a member of the human microbiota. (LLM, conf=0.88)
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Research works printed but not linked: 6
- DEs PREz, R. M., FALLON, N. & HooK, E. W. (1960). Modification of lethal effect of bacterial endotoxin by substances altering the metabolism of 5-hydroxytryptamine. Proc. Soc. exp. Biol., N.Y., 107, 529–534.
- GILBERT, R. P. (1959). Effect of antihistaminic and antiserotonin drugs on vascular responses to E. coli endotoxin in the cat. Proc. Soc. exp. Biol., N. Y.. 100, 346–349.
- GoRDoN, H. A., WAGNER, M. & WosTMANN, B. S. (1957–8). Studies on conventional and germfree chickens treated orally with antibiotics. Antibiotics Ann., ed. WELCH, H., pp. 248–255. New York: Medical Encyclopedia, Inc.
- REYNIERS, J. A., TREXLER, P. C., ERVIN, R. F., WAGNER, M., LUCKEY, T. D. & GORDON, H. A. (1949). Lobund Reports No. 2, pp. 1–116. Notre Dame, Ind., U.S.A.: University of Notre Dame.
- UDENFRIEND, S., WEISSBACH, H. & BRoDIE, H. (1958). Assay of serotonin and related metabolites, enzymes and drugs. Methods of Biochemical Analysis, Vol. 6, p. 95. New York: Interscience Publishers, Inc.
- WAGNER, M. & WosTMANN, B. S. (1958-9). Studies on monocontaminated chickens fed penicillin. Antibiotics Ann., ed. WELsH, H., pp. 1003–1011. New York: Antibiotica, Inc.
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Bosi, A., Banfi, D., Bistoletti, M., Giaroni, C., & Baj, A. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920928984 · Cited by 221 · see citing works
- Authors
- BEAVER, M. H., & WOSTMANN, B. S.
- Affiliations
- University of Notre Dame (US)
- Venue
- British Journal of Pharmacology and Chemotherapy
- Publisher
- Wiley
- Published
- 1962-12
- Volume
- 19
- Issue
- 3
- Pages
- 385-393
- ISSN
- 0366-0826 (ISSN-L)
- PMC
- PMC1482218
- OpenAlex
- W2095169676
- Cited by
- 63
- References
- 0
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 12 · 2020: 4 · 2019: 2 · 2014: 1 · 2013: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- British Journal of Pharmacology and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- histamine, serotonin, gut microbiota, germ-free animals, Clostridium perfringens, cecum, small intestine, penicillin, chickens, rats, mice
- MeSH terms
- Animals, Cecum, Clostridium perfringens, Germ-Free Life, Histamine, Intestine, Small, Intestines, Serotonin, Mice, Rats
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