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THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD
Open accessAbstract
A method is described for the assay of circulating hormones after their injection or release into the circulation. The method is applicable to cats, dogs and rabbits, and consists of bathing or superfusing isolated smooth muscle preparations in a stream of heparinized arterial blood taken from and returned to the animal at a constant rate. The tone of the smooth muscle preparations was affected by small changes in the concentrations of various amines. Thus increases in blood concentrations of catechol amines can be assayed with the rat stomach strip and chick rectum preparations. The proportions of adrenaline and noradrenaline in a mixture can be determined. Circulating histamine can be assayed on the blood‐bathed guinea‐pig ileum and bradykinin on the rat duodenum preparations. The uses and limitations of the technique are discussed.
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Vane, J. R., & Botting, R. M. (2003) · Thrombosis Research · doi:10.1016/s0049-3848(03)00379-7 · Cited by 1,225
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Vane, J. R., & Botting, R. M. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00203-9 · Cited by 688
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Curtis, M. J., Alexander, S. P. H., Cirino, G., George, C. H., Kendall, D. A., Insel, P. A., Izzo, A. A., Ji, Y., Panettieri, R. A., Patel, H. H., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15868 · Cited by 520
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Metadata
- Authors
- VANE, J. R.
- Venue
- British Journal of Pharmacology and Chemotherapy
- Publisher
- Wiley
- Published
- 1964-10
- Volume
- 23
- Issue
- 2
- Pages
- 360-373
- ISSN
- 0366-0826 (ISSN-L)
- OpenAlex
- W3144245776
- Cited by
- 472
- References
- 0
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD. https://app.cochat.ai/papers/10.1111/j.1476-5381.1964.tb01592.x
- The paper
- VANE, J. R. (1964). THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD. British Journal of Pharmacology and Chemotherapy. https://doi.org/10.1111/j.1476-5381.1964.tb01592.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
