The DOI matches its Crossref record.
UPTAKE OF NORADRENALINE BY ADRENERGIC NERVES, SMOOTH MUSCLE AND CONNECTIVE TISSUE IN ISOLATED PERFUSED ARTERIES AND ITS CORRELATION WITH THE VASOCONSTRICTOR RESPONSE
Open accessAbstract
Perfusion of the cat spleen with blood containing large quantities of noradrenaline causes the smooth muscle cells, when exposed to formaldehyde vapour, to develop the fluorescence characteristic of this catecholamine (Gillespie & Hamilton, 1967).The development of fluorescence is paralleled by the retention of noradrenaline assayed biochemically (Gillespie, Hamilton & Hosie, 1967).The smooth muscle cells differed both in the degree to which they retained noradrenaline and in the site of retention; in trabecular and capsular smooth muscle the fluorescence was slight and confined to the periphery of the cells, whereas in the smooth muscle of arteries the fluorescence was intense and present within the cells.In the perfused spleen it was difficult to be sure that all smooth muscle cells were equally exposed to noradrenaline and in the present experiments with an isolated length of artery perfused with saline it was hoped to minimize this difficulty so that the relationship between the concentration of noradrenaline and the degree of fluorescence could be determined.In the experiments on the spleen, the a-receptor blocking agent phenoxybenzamine prevented the development of fluorescence of arterial smooth muscle (Gillespie & Hamilton, 1966), suggesting that a-receptors might be involved in the uptake.If this were so, one would expect phenoxy- benzamine to interfere with the development of fluorescence and with the response in a parallel fashion.The vasoconstrictor response is easily measured in the perfused artery and it is therefore very suitable for this correlation.A brief account of some of these results has previously been published (Avakian & Gillespie, 1967). METHODSThe saline-perfused isolated artery preparation described by de la Lande & Rand (1965) was used.Rabbits of either sex in the weight range 1.8-2.8kg were anaesthetized with intravenous pentobarbitone
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Norepinephrine is a potent vasoconstrictor.
“NE is known to be a potent vasoconstrictor36,37.”
From Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep (2025) · cites this paper as [36]
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Research works printed but not linked: 23
- 10.1111/j.1748-1716.1966.tb03317.x · DOI
- Avakian O. V., 1967, The relationship between the development of fluorescence on and the response of arterial smooth muscle perfused with noradrenaline, J. Physiol., Lond., 191, 71
- 10.1111/j.1748-1716.1964.tb02874.x · DOI
- Costa E., 1966, Interactions of drugs with adrenergic neurons, Pharmac. Rev., 18, 577, 10.1016/S0031-6997(25)07195-9 · DOI
- 10.1111/j.1748-1716.1966.tb03314.x · DOI
- Dearnaley D. P., 1966, Changes in the distribution and content of noradrenaline in the spleen produced by nerve stimulation, J. Physiol., Lond., 186, 20
- 10.1038/212524a0 · DOI
- Gillespie J. S., 1967, A possible transport of noradrenaline into arterial smooth muscle cells, J. Physiol., Lond., 192, 30P
- Gillespie J. S., 1967, The relationship between development of tissue fluorescence and the retention of infused noradrenaline, J. Physiol., Lond., 190, 38
- 10.1113/jphysiol.1965.sp007545 · DOI
- 10.1113/jphysiol.1966.sp008076 · DOI
- 10.1113/jphysiol.1966.sp008075 · DOI
- Gillis O. N., 1966, Biochemical and micro‐fluorometric studies of norepinephrine redistribution accompanying sympathetic nerve stimulation, J. Pharmac. exp. Ther., 151, 46, 10.1016/S0022-3565(25)27226-3 · DOI
- Hamberger B., 1967, Reserpine‐resistant uptake of catecholamines in isolated tissues of the rat, Acta physiol. scand., 70
- 10.1111/j.1600-0773.1965.tb01831.x · DOI
- 10.1111/j.1748-1716.1967.tb03485.x · DOI
- 10.1038/189066a0 · DOI
- 10.1111/j.1476-5381.1965.tb01753.x · DOI
- Iversen L. L., 1965, Adv. Drug Res, 1
- 10.1038/icb.1965.48 · DOI
- Norberg K.‐A., 1964, The sympathetic adrenergic neuron. Some characteristics revealed by histochemical studies on the intraneuronal distribution of the transmitter, Acta physiol. scand., 63
- 10.1161/01.RES.3.6.553 · DOI
- Stromblad B. C. R., 1961, Accumulation of epinephrine and norepinephrine by some rat tissues, J. Pharmac., 134, 154
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Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Hauglund, N. L., Andersen, M., Tokarska, K., Radovanovic, T., Kjaerby, C., Sørensen, F. L., Bojarowska, Z., Untiet, V., Ballestero, S. B., Kolmos, M. G., et al. (2025) · Cell · doi:10.1016/j.cell.2024.11.027 · Cited by 349
Metadata
- Authors
- AVAKIAN, O. V., & GILLESPIE, J. S.
- Affiliations
- A. Mnjoyan Institute of Fine Organic Chemistry (AM)
- University of Glasgow (GB)
- Venue
- British Journal of Pharmacology and Chemotherapy
- Publisher
- Wiley
- Published
- 1968-01
- Volume
- 32
- Issue
- 1
- Pages
- 168-184
- ISSN
- 0366-0826 (ISSN-L)
- PMC
- PMC1570308
- OpenAlex
- W2036702791
- Cited by
- 129
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Pharmacology and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- norepinephrine uptake, adrenergic nerves, vascular smooth muscle, connective tissue, vasoconstriction, alpha-adrenergic receptors, phenoxybenzamine, spleen perfusion
- MeSH terms
- Animals, Arteries, Connective Tissue, Ear, Female, Fluorescence, Male, Muscle, Smooth, Nerve Endings, Norepinephrine, Phenoxybenzamine, Phentolamine, Photometry, Propranolol, Rabbits, Vasomotor System
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