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Resistance to β‐adrenoceptor stimulants (a possible explanation for the rise in asthma deaths)
Open accessAbstract
Summary: Resistance to isoprenaline has been produced in man and dog by prolonged exposure to the same, or the pharmacologically similar compounds, terbutaline and isoetharine. In guinea‐pigs, pretreatment with these agents increases asthma mortality provoked by histamine which suggests that this resistance may reduce the effectiveness of endogenous sympathetic drive to the bronchi. Possible mechanisms by which the asthma death rate could be increased are discussed. It is suggested that a drug‐induced cross resistance to endogenous sympathetic stimulation could have led to a deterioration of the asthmatic state in patients using the pressurized aerosols of sympathomimetic bronchodilators and that this might account for the rise in asthma death rate.
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Citations
Cited by
Tolerance to the Nonbronchodilator Effects of Inhaled β2-Agonists in Asthma
O'Connor, B. J., Aikman, S. L., & Barnes, P. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199210223271704 · Cited by 349
Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81.
Pearce, N., Grainger, J., Atkinson, M., Crane, J., Burgess, C., Culling, C., Windom, H., & Beasley, R. (1990) · Thorax · doi:10.1136/thx.45.3.170 · Cited by 297
Tsagaraki, V., Amfilochiou, A., & Markantonis, S. L. (2006) · International Journal of Clinical Practice · doi:10.1111/j.1368-5031.2006.00849.x · Cited by 24
Koryakina, Y., Jones, S. M., Cornett, L. E., Seely, K., Brents, L., Prather, P. L., Kofman, A., & Kurten, R. C. (2012) · Cell Biology International · doi:10.1042/cbi20120134 · Cited by 12
Metadata
- Authors
- CONOLLY, M. E., DAVIES, D. S., DOLLERY, C. T., & GEORGE, C. F.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1971-10
- Volume
- 43
- Issue
- 2
- Pages
- 389-402
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W4388352228
- Cited by
- 212
- References
- 0
- FWCI
- 15.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Resistance to β‐adrenoceptor stimulants (a possible explanation for the rise in asthma deaths). https://app.cochat.ai/papers/10.1111/j.1476-5381.1971.tb08070.x
- The paper
- CONOLLY, M. E., DAVIES, D. S., DOLLERY, C. T., & GEORGE, C. F. (1971). Resistance to β‐adrenoceptor stimulants (a possible explanation for the rise in asthma deaths). British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1971.tb08070.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
