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Action of fenfluramine on monoamine stores of rat tissues
Open accessAbstract
Summary: Fenfluramine is an anorexogenic agent used clinically because it is devoid of central stimulatory effects. In rats, fenfluramine causes a depletion of 5‐hydroxytryptamine (5‐HT) from the telencephalon + diencephalon which lasts longer than one might have expected from the biological half life of fenfluramine. The depleting effects of fenfluramine do not extend to brainstem, stomach and heart stores of 5‐HT. Fenfluramine causes an increase in the turnover rate of tel‐diencephalic 5‐HT but such an acceleration could not be detected in the 5‐HT stores of the brainstem. It is inferred that the effects of fenfluramine on brain 5‐hydroxytryptamine may be related to the accumulation of a fenfluramine metabolite in 5‐HT neurones. High doses of fenfluramine cause a depletion of catecholamine stores in brain and heart but the time course of this depletion is shorter than the depletion of brain 5‐HT.
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Cited by
Dynamics and Consequences of Potassium Shifts in Skeletal Muscle and Heart During Exercise
Sejersted, O. M., & Sjøgaard, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1411 · Cited by 490
Neurobiology of an anorectic drug: Fenfluramine
Rowland, N. E., & Carlton, J. (1986) · Progress in Neurobiology · doi:10.1016/0301-0082(86)90011-0 · Cited by 314
Anti-obesity therapy: from rainbow pills to polyagonists
Müller, T. D., Clemmensen, C., Finan, B., DiMarchi, R. D., & Tschöp, M. H. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014803 · Cited by 199
Metadata
- Authors
- COSTA, E., GROPPETTI, A., & REVUELTA, A.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1971-01
- Volume
- 41
- Issue
- 1
- Pages
- 57-64
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2148634234
- Cited by
- 183
- References
- 0
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- COSTA, E., GROPPETTI, A., & REVUELTA, A. (1971). Action of fenfluramine on monoamine stores of rat tissues. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1971.tb09935.x
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