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The ring test: a quantitative method for assessing the ‘cataleptic’ effect of cannabis in mice
Open accessAbstract
Summary: . A bioassay for cannabis, called the ring test, has been developed in which the percentage of the total time spent on a horizontal wire ring during which a mouse remains completely immobile is recorded. . The effect of cannabis on mobility is a dose‐related, graded response. . Threshold doses of cannabis extract are 12·5 mg/kg when injected intravenously, and 100 mg/kg when injected intraperitoneally or subcutaneously. . The method provides a measure of the ‘cataleptic’ effect of cannabis. Chlorpromazine in doses of 1 mg/kg upwards also produces the effect but barbitone does not. . It is concluded that Δ 1‐tetrahydrocannabinol (Δ 1‐THC) is largely responsible for the effect of cannabis extract on mobility; the potency ratio of Δ 1‐THC to cannabis extract is between 10 and 20. Δ 1‐Tetrahydrocannabidivarol (Δ 1‐THD) also affects mobility but is less active than Δ 1‐THC. Cannabidiol has no effect when injected intraperitoneally in doses up to 100 mg/kg.
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Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
Self-citationSR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi-Carmona, M., Barth, F., Héaulme, M., Shire, D., Calandra, B., Congy, C., Martinez, S., Maruani, J., Néliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,757
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Agarwal, N., Pacher, P., Tegeder, I., Amaya, F., Constantin, C. E., Brenner, G. J., Rubino, T., Michalski, C. W., Marsicano, G., Monory, K., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1916 · Cited by 571
Safety and side effects of cannabidiol, a Cannabis sativa constituent
Machado Bergamaschi, M., Helena Costa Queiroz, R., Waldo Zuardi, A., & Alexandre S. Crippa, J. (2011) · Current Drug Safety · doi:10.2174/157488611798280924 · Cited by 558
Ligresti, A., De Petrocellis, L., & Di Marzo, V. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2016 · Cited by 469
Metadata
- Authors
- PERTWEE, R. G.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1972-12
- Volume
- 46
- Issue
- 4
- Pages
- 753-763
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2009051797
- Cited by
- 188
- References
- 0
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The ring test: a quantitative method for assessing the ‘cataleptic’ effect of cannabis in mice. https://app.cochat.ai/papers/10.1111/j.1476-5381.1972.tb06900.x
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- PERTWEE, R. G. (1972). The ring test: a quantitative method for assessing the ‘cataleptic’ effect of cannabis in mice. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1972.tb06900.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
