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INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKIN
Open accessAbstract
Intradermal injection of prostaglandin (PG) D 1 and D 2 in the human forearm produced a long‐lasting dose‐related erythema. When compared with prostaglandin E 1 or E 2 the order of potency for erythema production was PGE 1 > PGE 2 > PGD 2 > PGD 1. In rat skin, prostaglandin D 2 but not D 1 caused an increase in vascular permeability as quantitated by the Evans blue method and the 125 I‐albumin extravasation technique. Prostaglandin E 2 was 3–5 times more potent than prostaglandin D 2. Prostaglandin D 2 (10 ng) potentiated the increase in vascular permeability in rat skin produced by histamine, but not that produced by bradykinin. Prostaglandin D 2 (10, 20 and 50 ng) did not elicit oedema or hyperalgesia in the rat paw oedema test, but potentiated carrageenan‐induced oedema; hyperalgesia was potentiated by doses of 100 ng and above.
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Cited by
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PROSTAGLANDIN E2, PROSTAGLANDIN I2 AND THE VASCULAR CHANGES OF INFLAMMATION
WILLIAMS, T. J. (1979) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1979.tb07860.x · Cited by 344
Iwasaki, M., Nagata, K., Takano, S., Takahashi, K., Ishii, N., & Ikezawa, Z. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01862.x · Cited by 86
Aeroallergens in atopic dermatitis and chronic urticaria
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Metadata
- Authors
- FLOWER, R. J., HARVEY, E. A., & KINGSTON, W. P.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1976-02
- Volume
- 56
- Issue
- 2
- Pages
- 229-233
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1967312698
- Cited by
- 195
- References
- 0
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- FLOWER, R. J., HARVEY, E. A., & KINGSTON, W. P. (1976). INFLAMMATORY EFFECTS OF PROSTAGLANDIN D2 IN RAT AND HUMAN SKIN. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1976.tb07446.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
