ALTERATION IN THE LEVEL OF ENDOGENOUS HYPOTHALAMIC PROSTAGLANDINS INDUCED BY Δ 9‐TETRAHYDROCANNABINOL IN THE RAT

Whole brain and regional brain levels of prostaglandin E 2 (PGE 2 )‐like material have been determined following administration of Δ 9 ‐tetrahydrocannabinol (Δ 9 ‐THC) in rats. Intravenous administration of Δ 9 ‐THC 2 mg/kg, resulted in marked behavioural changes and hypothermia. The behavioural …