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Cited by 525

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Endothelium‐dependent inhibition of platelet aggregation

Open access
Azuma, Hiroshi, Ishikawa, Masayuki, Sekizaki, Satomi·1986·British Journal of Pharmacology

Abstract

In cascade perfusion and superfusion experiments on rabbit tissues, when acetylcholine (ACh) was introduced into the circuit so as to perfuse the aorta under perfusion with noradrenaline (NA), the effluent relaxed the transverse aortic strip which had been denuded of endothelium. The effluent from the perfused aorta which was capable of relaxing the transverse aortic strip also significantly inhibited platelet aggregation induced by arachidonic acid (AA) in a volume‐related manner. The inhibitory activity was decreased by the prolongation of transit time before addition of the effluent to platelet‐rich plasma. Neither the inhibition of AA‐induced aggregation nor the relaxation of the transverse strip by the effluent could be observed after the removal of endothelium from the aorta, or after pretreatment of aorta with mepacrine or nordihydroguaiaretic acid (NDGA). The AA‐induced platelet aggregation was unaffected by pretreatment of platelets with mepacrine or NDGA at the concentration tested. Pretreatment of aorta with indomethacin failed to modify the relaxation of the transverse strip induced by the effluent. These results strongly suggest that endothelium‐derived vascular relaxant factor (EDRF) possesses inhibitory activity on AA‐induced aggregation in addition to its vasodilator activity.

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Crossref · 10.1111/j.1476-5381.1986.tb10218.x

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Metadata

Authors
Azuma, H., Ishikawa, M., & Sekizaki, S.
Venue
British Journal of Pharmacology
Publisher
Wiley
Published
1986-06
Volume
88
Issue
2
Pages
411-415
ISSN
  • 0007-1188 (ISSN-L)
  • 1476-5381
OpenAlex
W2045980084
Cited by
525
References
17
FWCI
20.43
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Endothelium‐dependent inhibition of platelet aggregation. https://app.cochat.ai/papers/10.1111/j.1476-5381.1986.tb10218.x
The paper
Azuma, H., Ishikawa, M., & Sekizaki, S. (1986). Endothelium‐dependent inhibition of platelet aggregation. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1986.tb10218.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.