The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets
Open accessAbstract
The pharmacological effects of endothelium‐derived relaxing factor (EDRF), nitric oxide (NO) and prostacyclin on human and rabbit platelets were examined. EDRF is released from porcine aortic endothelial cells, cultured on microcarriers and treated with indomethacin, in sufficient quantities to inhibit platelet aggregation induced by 9,11‐dideoxy‐9α,11α‐methano epoxy‐prostaglandin F 2α (U46619) and collagen. The anti‐aggregating activity of EDRF was potentiated by M&B 22948, a selective inhibitor of cyclic GMP phosphodiesterase, and by superoxide dismutase (SOD) and was inhibited by haemoglobin and Fe 2+. Both NO and prostacyclin inhibited platelet aggregation. The anti‐aggregatory activity of NO, but not that of prostacyclin, was potentiated by M&B 22948 and by SOD and was inhibited by haemoglobin and Fe 2+. Thus NO is a potent inhibitor of platelet aggregation whose activity on platelets mimics that of EDRF. It is likely that the inhibitory effect of NO on platelets represents the action of endogenous EDRF and therefore this substance, together with prostacyclin, is a regulator of platelet‐vessel wall interactions.
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Citations
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Self-citationRapoport, R. M., Draznin, M. B., & Murad, F. (1983) · Nature · doi:10.1038/306174a0 · Cited by 631
Gryglewski, R. J., Moncada, S., & Palmer, R. M. J. (1986) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1986.tb14586.x · Cited by 200
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Cited by
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437
Self-citationNitric oxide donors: chemical activities and biological applications
Wang, P. G., Xian, M., Tang, X., Wu, X., Wen, Z., Cai, T., & Janczuk, A. J. (2002) · Chemical Reviews · doi:10.1021/cr000040l · Cited by 1,337
Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide
Ignarro, L. J. (1990) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.002535 · Cited by 1,314
An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.
Radomski, M. W., Palmer, R. M., & Moncada, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5193 · Cited by 1,208
Self-citationEndogenous nitric oxide: physiology, pathology and clinical relevance
MONCADA, S., & HIGGS, E. A. (1991) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1991.tb01383.x · Cited by 759
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Metadata
- Authors
- Radomski, M. W., Palmer, R. M. J., & Moncada, S.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1987-09
- Volume
- 92
- Issue
- 1
- Pages
- 181-187
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2171278791
- Cited by
- 816
- References
- 3
- FWCI
- 30.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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