The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide
Open accessAbstract
1. The interactions between endothelium-derived nitric oxide (NO) and prostacyclin as inhibitors of platelet aggregation were examined. 2. Porcine aortic endothelial cells treated with indomethacin and stimulated with bradykinin (10-100 nM) released NO in quantities sufficient to account for the inhibition of platelet aggregation attributed to endothelium-derived relaxing factor (EDRF). 3. In the absence of indomethacin, stimulation of the cells with bradykinin (1-3 nM) released small amounts of prostacyclin and EDRF which synergistically inhibited platelet aggregation. 4. EDRF and authentic NO also caused disaggregation of platelets aggregated either with collagen or with U46619. 5. A reciprocal potentiation of both the anti- and the dis-aggregating activity was also observed between low concentrations of prostacyclin and authentic NO or EDRF released from endothelial cells. 6. It is likely that interactions between prostacyclin and NO released by the endothelium play a role in the homeostatic regulation of platelet-vessel wall interactions.
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Citations
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Self-citationGryglewski, R. J., Moncada, S., & Palmer, R. M. J. (1986) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1986.tb14586.x · Cited by 200
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Cited by
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687
Drinking Water Nitrate and Human Health: An Updated Review
Ward, M., Jones, R., Brender, J., De Kok, T., Weyer, P., Nolan, B., Villanueva, C., & Van Breda, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15071557 · Cited by 1,576
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437
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Metadata
- Authors
- Radomski, M. W., Palmer, R. M. J., & Moncada, S.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1987-11
- Volume
- 92
- Issue
- 3
- Pages
- 639-646
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2104380573
- Cited by
- 1,164
- References
- 2
- FWCI
- 27.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987). The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1987.tb11367.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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