The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The potential anxiolytic activity of GR38032F, a 5‐HT3‐receptor antagonist
Open accessAbstract
1. The highly selective 5-HT3-receptor antagonist, GR38032F, has been tested in five animal models predictive for anxiolytic activity. 2. In the social interaction test in the rat and in a light/dark exploration test in the mouse, GR38032F dose-dependently released suppressed behaviour without modifying locomotor activity. 3. In the cynomolgus monkey and the marmoset, GR38032F reduced anxiety-related symptoms without causing sedation. In the marmoset, the effects were clearly dose-related. 4. GR38032F did not have any detectable activity in the water-lick conflict test in the rat. 5. We conclude that GR38032F is potentially a very potent anxiolytic agent without sedative, anticonvulsant or hypnotic activity.
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Cites
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., & Saxena, P. R. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90207-8 · Cited by 1,258
Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding
Kilpatrick, G. J., Jones, B. J., & Tyers, M. B. (1987) · Nature · doi:10.1038/330746a0 · Cited by 865
Self-citationA simple and reliable conflict procedure for testing anti-anxiety agents
Vogel, J. R., Beer, B., & Clody, D. E. (1971) · Psychopharmacologia · doi:10.1007/bf00403989 · Cited by 841
File, S. E. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90012-6 · Cited by 815
CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?
FILE, S. E., & HYDE, J. R. G. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb07001.x · Cited by 803
The pharmacology and function of 5-HT3receptors
Richardson, B. P., & Engel, G. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90137-2 · Cited by 383
Pharmacological properties of GR38032F, a novel antagonist at 5‐HT3 receptors
Butler, A., Hill, J. M., Ireland, S. J., Jordan, C. C., & Tyers, M. B. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11542.x · Cited by 374
Self-citationSelective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors
Peroutka, S. J. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90194-5 · Cited by 369
IVERSEN, S. (1984) · Neuropharmacology · doi:10.1016/0028-3908(84)90099-6 · Cited by 322
An ethogram of the common marmoset (Calithrix jacchus jacchus): General behavioural repertoire
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Cited by
A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,161
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 965
Ethologically-based animal models of anxiety disorders
Lister, R. G. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90021-s · Cited by 845
A review of 25 years of the social interaction test
File, S. E., & Seth, P. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01273-1 · Cited by 742
Interneuron Diversity series: Rhythm and mood in perisomatic inhibition
Freund, T. F. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00227-3 · Cited by 641
Metadata
- Authors
- Jones, B. J., Costall, B., Domeney, A. M., Kelly, M. E., Naylor, R. J., Oakley, N. R., & Tyers, M. B.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1988-04
- Volume
- 93
- Issue
- 4
- Pages
- 985-993
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2019012629
- Cited by
- 327
- References
- 14
- FWCI
- 16.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The potential anxiolytic activity of GR38032F, a 5‐HT3‐receptor antagonist. https://app.cochat.ai/papers/10.1111/j.1476-5381.1988.tb11489.x
- The paper
- Jones, B. J., Costall, B., Domeney, A. M., Kelly, M. E., Naylor, R. J., Oakley, N. R., & Tyers, M. B. (1988). The potential anxiolytic activity of GR38032F, a 5‐HT3‐receptor antagonist. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1988.tb11489.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
