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A specific B2‐bradykinin receptor antagonist HOE 140 abolishes the antihypertrophic effect of ramipril
Open accessAbstract
To evaluate the role of bradykinin in the antihypertrophic effect of the angiotensin‐converting enzyme (ACE) inhibitor, ramipril, we investigated the influence of HOE 140, a specific B 2‐receptor antagonist, on the effects of ramipril on left ventricular hypertrophy (LVH) in rats with aortic banding. Ramipril at a dose of 1 mg kg−1 day−1 for 6 weeks prevented the increase in blood pressure and development of LVH after aortic banding; plasma ACE activity was significantly inhibited. A lower dose of ramipril (10 μg kg−1 May−1 for 6 weeks) had no effect on the increase in blood pressure or on plasma ACE activity, but prevented LVH after aortic banding. The antihypertrophic effects of the higher and the lower dose ramipril, as well as the antihypertensive action of the higher dose of ramipril were abolished by the coadministration of HOE 140 (500 μg kg−1 day−1). The present data show for the first time that the beneficial effects of an ACE‐inhibitor on LVH in rats with hypertension caused by aortic banding can be prevented by a specific B 2‐receptor antagonist.
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Cited by
WRITING COMMITTEE MEMBERS, Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.167586 · Cited by 2,251
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., Michl, K., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.013 · Cited by 1,374
Angiotensin-Converting Enzyme Inhibitors
Brown, N. J., & Vaughan, D. E. (1998) · Circulation · doi:10.1161/01.cir.97.14.1411 · Cited by 958
Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697
Angiotensin II Type 1 Receptor Blockers
Burnier, M. (2001) · Circulation · doi:10.1161/01.cir.103.6.904 · Cited by 485
Metadata
- Authors
- Linz, W., & Schölkens, B. A.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 1992-04
- Volume
- 105
- Issue
- 4
- Pages
- 771-772
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W2019114393
- Cited by
- 236
- References
- 0
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Linz, W., & Schölkens, B. A. (1992). A specific B2‐bradykinin receptor antagonist HOE 140 abolishes the antihypertrophic effect of ramipril. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.1992.tb09054.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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