A crucial role for TNF‐α in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5

Vieira, SM; Lemos, HP; Grespan, R; Napimoga, MH; Dal‐Secco, D; Freitas, A; Cunha, TM; Verri Jr, WA; Souza‐Junior, DA; Jamur, MC; Fernandes, KS; Oliver, C; Silva, JS; Teixeira, MM; Cunha, FQ

doi:10.1111/j.1476-5381.2009.00367.x

A crucial role for TNF‐α in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5

Background and purpose: Chemokines orchestrate neutrophil recruitment to inflammatory foci. In the present study, we evaluated the participation of three chemokines, KC/CXCL1, MIP‐2/CXCL2 and LIX/CXCL5, which are ligands for chemokine receptor 2 (CXCR2), in mediating neutrophil recruitment in imm…