The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
Open accessAbstract
The human organic anion and cation transporters are classified within two SLC superfamilies. Superfamily SLCO(formerly SLC21A) consists of organic anion transporting polypeptides (OATPs), while the organic anion transporters (OATs) and the organic cation transporters (OCTs) are classified in the SLC22A superfamily. Individual members of each superfamily are expressed in essentially every epithelium throughout the body, where they play a significant role in drug absorption, distribution and elimination. Substrates of OATPs are mainly large hydrophobic organic anions, while OATs transport smaller and more hydrophilic organic anions and OCTs transport organic cations. In addition to endogenous substrates, such as steroids, hormones and neurotransmitters, numerous drugs and other xenobiotics are transported by these proteins, including statins, antivirals, antibiotics and anticancer drugs. Expression of OATPs, OATs and OCTs can be regulated at the protein or transcriptional level and appears to vary within each family by both protein and tissue type. All three superfamilies consist of 12 transmembrane domain proteins that have intracellular termini. Although no crystal structures have yet been determined, combinations of homology modelling and mutation experiments have been used to explore the mechanism of substrate recognition and transport. Several polymorphisms identified in members of these superfamilies have been shown to affect pharmacokinetics of their drug substrates, confirming the importance of these drug transporters for efficient pharmacological therapy. This review, unlike other reviews that focus on a single transporter family, briefly summarizes the current knowledge of all the functionally characterized human organic anion and cation drug uptake transporters of the SLCO and the SLC22A superfamilies. LINKED ARTICLESBJP recently published a themed section on Transporters. To view the papers in this section visit http://dx.doi.org/10.1111/bph.2011.164.issue‐7
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Cites
Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter
Gründemann, D., Schechinger, B., Rappold, G., & Schömig, E. (1998) · Nature Neuroscience · doi:10.1038/1557 · Cited by 374 · cited 2×
“OCT1 and OCT2 have 70% amino acid identity to each other, and approximately 50% identity with OCT3 (Gorboulev et al., 1997; Zhang et al., 1997; Grundemann et al., 1998).”
BackgroundMethodRoberts, L. M., Woodford, K., Zhou, M., Black, D. S., Haggerty, J. E., Tate, E. H., Grindstaff, K. K., Mengesha, W., Raman, C., & Zerangue, N. (2008) · Endocrinology · doi:10.1210/en.2008-0378 · Cited by 320
Treiber, A., Schneiter, R., Häusler, S., & Stieger, B. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.013615 · Cited by 299
Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology
VanWert, A. L., Gionfriddo, M. R., & Sweet, D. H. (2010) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.693 · Cited by 252
Human skeletal muscle drug transporters determine local exposure and toxicity of statins
Knauer, M. J., Urquhart, B. L., Meyer zu Schwabedissen, H. E., Schwarz, U. I., Lemke, C. J., Leake, B. F., Kim, R. B., & Tirona, R. G. (2010) · Circulation Research · doi:10.1161/circresaha.109.203596 · Cited by 222
Cited by
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Chakarov, S., Lim, H. Y., Tan, L., Lim, S. Y., See, P., Lum, J., Zhang, X.-M., Foo, S., Nakamizo, S., Duan, K., et al. (2019) · Science · doi:10.1126/science.aau0964 · Cited by 1,114
The Regulation of Steroid Action by Sulfation and Desulfation
Mueller, J. W., Gilligan, L. C., Idkowiak, J., Arlt, W., & Foster, P. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1036 · Cited by 419
Bioaccumulation of Perfluorinated Alkyl Acids: Observations and Models
Ng, C. A., & Hungerbühler, K. (2014) · Environmental Science & Technology · doi:10.1021/es404008g · Cited by 393
Groeneweg, S., van Geest, F. S., Peeters, R. P., Heuer, H., & Visser, W. E. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz008 · Cited by 216
Metadata
- Authors
- Roth, M., Obaidat, A., & Hagenbuch, B.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2012-02-10
- Volume
- 165
- Issue
- 5
- Pages
- 1260-1287
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1550259003
- Cited by
- 767
- References
- 5
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Roth, M., Obaidat, A., & Hagenbuch, B. (2012). OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. British Journal of Pharmacology. https://doi.org/10.1111/j.1476-5381.2011.01724.x
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