The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
The functions of TRPA1 and TRPV1: moving away from sensory nerves
Open accessAbstract
The transient receptor potential vanilloid 1 and ankyrin 1 (TRPV1 and TRPA1, respectively) channels are members of the TRP superfamily of structurally related, non‐selective cation channels. It is rapidly becoming clear that the functions of TRPV1 and TRPA1 interlink with each other to a considerable extent. This is especially clear in relation to pain and neurogenic inflammation where TRPV1 is coexpressed on the vast majority of TRPA1‐expressing sensory nerves and both integrate a variety of noxious stimuli. The more recent discovery that both TRPV1 and TRPA1 are expressed on a multitude of non‐neuronal sites has led to a plethora of research into possible functions of these receptors. Non‐neuronal cells on which TRPV1 and TRPA1 are expressed vary from vascular smooth muscle to keratinocytes and endothelium. This review will discuss the expression, functionality and roles of these non‐neuronal TRP channels away from sensory nerves to demonstrate the diverse nature of TRPV1 and TRPA1 in addition to a direct role in pain and neurogenic inflammation.
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Cites
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Transient Receptor Potential Channels in the Vasculature
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Peripheral changes in endometriosis-associated pain
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Xie, Z., Feng, J., Hibberd, T. J., Chen, B. N., Zhao, Y., Zang, K., Hu, X., Yang, X., Chen, L., Brookes, S. J., et al. (2023) · Neuron · doi:10.1016/j.neuron.2022.11.015 · Cited by 84
Metadata
- Authors
- Fernandes, E., Fernandes, M., & Keeble, J.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2012-04-13
- Volume
- 166
- Issue
- 2
- Pages
- 510-521
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1582245657
- Cited by
- 411
- References
- 118
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- green
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