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A double-blind, randomized, placebo-controlled trial of intravenous l-ornithine-l-aspartate on postural control in patients with cirrhosis

Schmid, Monika, Peck-Radosavljevic, Markus, König, Franz, Mittermaier, Christian, Gangl, Alfred, Ferenci, Peter·2010·Liver International
DOI 10.1111/j.1478-3231.2010.02213.x
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Abstract

Introduction Hepatic encephalopathy (HE) is a complication of liver disease. Several treatments have been introduced but only L-ornithine-L-aspartate (LOLA) shows proven efficacy. This double-blind, randomized, placebo-controlled trial evaluated the effect of LOLA on postural control in cirrhotics. Methods Forty patients were randomized to either LOLA or a placebo. HE was evaluated by psychometric testing (PSE Syndrome Test) and critical flicker frequency (CFF). Posturography [equilibrium score (ES)] provided information regarding postural control. Peripheral blood was analysed for ammonia concentration (NH(3)) and the partial pressure of ammonia (pNH(3)). Results Both groups were comparable regarding baseline variables. Posturography and PSE Syndrome Test improved in both groups; improvement was greater in the LOLA group (ES: 5.3%; PSE: 1.9) compared with the placebo (ES: 3.9%; PSE: 1.3) but did not reach significance (ES: P=0.3; PSE: P=0.5). CFF remained unchanged during treatment and between groups (P=NS). NH(3) decreased in the LOLA group (Delta: -15 micromol/L) and slightly increased in the placebo group (Delta: 11.1 micromol/L), but the differences did not reach statistical significance (P=0.07). pNH(3) remained largely unchanged (LOLA Delta: -1.2 x 10(-5) mmHg vs. placebo Delta: -0.3 x 10(-5) mmHg; P=0.21). Conclusion In the LOLA group, an improvement of posturographic control and PSE Syndrome Test was observed, but a similar improvement was also achieved by the placeb…

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Metadata

Authors
Schmid, M., Peck-Radosavljevic, M., König, F., Mittermaier, C., Gangl, A., & Ferenci, P.
Venue
Liver International
Publisher
Wiley
Published
2010-04
Volume
30
Issue
4
Pages
574-582
ISSN
  • 1478-3223
  • 1478-3231
DOI
10.1111/j.1478-3231.2010.02213.x
Cited by
27
References
0
Language
en
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1979 d)

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